Bowel preparations for capsule endoscopy: a comparison between simethicone and magnesium citrate

Motohiro Esaki, Takayuki Matsumoto, Tetsuji Kudo, Ritsuko Yanaru-Fujisawa, Shotaro Nakamura, Mitsuo Iida

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36 Citations (Scopus)


Background: Bowel preparation for capsule endoscopy (CE) has not been standardized. Objective: This study aimed to compare CE images between patients prepared by simethicone and those prepared by magnesium citrate. Design: Retrospective analysis of case series of our hospital from 2004 to 2007. Setting: Single center. Patients and Interventions: CE images of 75 patients receiving bowel preparation either by 200 mg of simethicone (n = 39) or by 34 g of magnesium citrate (n = 36) were retrospectively investigated. Grades of fluid transparency and mucosal invisibility by air bubbles and food residue were compared between the 2 preparations. Capsule transit time, frequency of positive findings, and interobserver variations between 2 observers were also investigated. Main Outcome Measurements: Image quality and diagnostic yield of CE. Results: Fluid transparency in the first and the third time segments of the small intestine was better in patients prepared by magnesium citrate than in those prepared by simethicone (P = .001 and P = .03, respectively). On the other hand, mucosal invisibility was not different in any part of the small intestine between the 2 groups. Neither gastric transit time nor small-bowel transit time was different between the 2 groups. The diagnostic yield of CE correlated significantly with fluid transparency (P = .04), but it did not correlate with mucosal invisibility. Limitations: Single-center retrospective study. Conclusion: Magnesium citrate seems to be a recommended preparation for CE compared with simethicone. The fluid transparency, rather than the mucosal invisibility, may be a factor associated with the diagnostic yield of CE.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalGastrointestinal endoscopy
Issue number1
Publication statusPublished - Jan 2009

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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