Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects

Hiroki Satoh, Yasuaki Saijo, Reiko Kishi, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives Cardiovascular morbidity and mortality are closely associated with hypertension, however, predictors of incident hypertension have not been fully established. We have conducted a study aimed at evaluating whether brachial-ankle pulse wave velocity (baPWV) is a predictor of incident hypertension. Methods The relation between baPWV, a noninvasive index of aortic stiffness, and incident hypertension was evaluated in a cohort of 2,278 Japanese normotensive male subjects with a follow-up of 3 years. Results Of the 2, 278 study participants, 151 (6.6%) had incident hypertension during the follow-up. After adjustment for variables, including age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes mellitus, hyperlipidemia, family history of hypertension, heart rate, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, and fasting plasma glucose, multiple logistic regression analysis revealed that baPWV was a significant and independent predictor of incident hypertension with an adjusted odds ratio 1.45 (95% confidence interval 1.17-1.79, <\0.01). In addition, baPWV values >1,380 cm/s indicated a high risk for incident hypertension. Conclusions Among the Japanese normotensive male subjects participating in this study, BaPWV was a significant and independent predictor of incident hypertension. This result suggests that BaPWV could be a useful screening method to identify normotensive individuals who should be targeted for interventions aimed at preventing the incident hypertension.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalEnvironmental Health and Preventive Medicine
Volume16
Issue number4
DOIs
Publication statusPublished - Jul 1 2011
Externally publishedYes

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Pulse Wave Analysis
Ankle
Arm
Hypertension
Blood Pressure
Vascular Stiffness
Hyperlipidemias
Alcohol Drinking
LDL Cholesterol
Habits
Fasting
Diabetes Mellitus
Body Mass Index
Heart Rate
Logistic Models
Smoking
Odds Ratio
Regression Analysis
Confidence Intervals
Morbidity

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects. / Satoh, Hiroki; Saijo, Yasuaki; Kishi, Reiko; Tsutsui, Hiroyuki.

In: Environmental Health and Preventive Medicine, Vol. 16, No. 4, 01.07.2011, p. 217-223.

Research output: Contribution to journalArticle

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