Brain death diagnosed by forensic analysis of drug distribution in human tissues-II - Distribution of caffeine in brain dead patients

N. Jitsufuchi, Keiko Kudo, T. Imamura, T. Nagata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Caffeine concentrations in human tissues of 6 brain death cases as well as 5 non-brain death cases were examined in order to assess the possibility of diagnosing brain death based on an analysis of this compound. Concentrations of caffeine in human tissues were determined using gas chromatography mass spectrometry. The tissue-to-blood concentration ratios were used to evaluate the distribution pattern in each case. In non-brain death cases, the ratios in all examined tissues were similar, and the values were close to 1 in all tissues except brain and adipose were similar to those in non-brain death cases. The ratios in the brain were higher than those of non-brain death cases, in 5 brain death cases and lower in 1 brain death case to whom blood transfusion was done in a hospital. The ratios in the adipose were slightly higher in brain death cases than those in non-brain death cases. The discorded distribution of caffeine in brain death cases was presumably related to cessation of cerebral blood circulation at the time of brain death. Therefore, comparing caffeine concentrations in the brain with those in the other tissue can be useful for a forensic diagnosis of brain death.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalJapanese Journal of Legal Medicine
Volume50
Issue number2
Publication statusPublished - Jun 3 1996

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Brain Death
Tissue Distribution
Caffeine
Pharmaceutical Preparations
Cerebrovascular Circulation
Brain
Blood Circulation Time
Blood Transfusion
Gas Chromatography-Mass Spectrometry

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Law

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Brain death diagnosed by forensic analysis of drug distribution in human tissues-II - Distribution of caffeine in brain dead patients. / Jitsufuchi, N.; Kudo, Keiko; Imamura, T.; Nagata, T.

In: Japanese Journal of Legal Medicine, Vol. 50, No. 2, 03.06.1996, p. 72-77.

Research output: Contribution to journalArticle

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