Brain redox imaging

Ken Ichiro Matsumoto, Fuminori Hyodo, Kazunori Anzai, Hideo Utsumi, James B. Mitchell, Murali C. Krishna

    Research output: Chapter in Book/Report/Conference proceedingChapter

    16 Citations (Scopus)

    Abstract

    Nitroxyl contrast agents (nitroxyl radicals, also known as nitroxide) are paramagnetic species, which can react with reactive oxygen species (ROS) to lose paramagnetism to be diamagnetic species. The paramagnetic nitroxyl radical forms can be detected by using electron paramagnetic resonance imaging (EPRI), Overhauser MRI (OMRI), or MRI. The time course of in vivo image intensity induced by paramagnetic redox-sensitive contrast agent can give tissue redox information, which is the so-called redox imaging technique. The redox imaging technique employing a blood-brain barrier permeable nitroxyl contrast agent can be applied to analyze the pathophysiological functions in the brain. A brief theory of redox imaging techniques is described, and applications of redox imaging techniques to brain are introduced.

    Original languageEnglish
    Title of host publicationMagnetic Resonance Neuroimaging
    Subtitle of host publicationMethods and Protocols
    EditorsMichel Modo, Jelte Bulte
    Pages397-419
    Number of pages23
    DOIs
    Publication statusPublished - 2010

    Publication series

    NameMethods in Molecular Biology
    Volume711
    ISSN (Print)1064-3745

    All Science Journal Classification (ASJC) codes

    • Molecular Biology
    • Genetics

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