Brain redox imaging

Ken Ichiro Matsumoto, Fuminori Hyodo, Kazunori Anzai, Hideo Utsumi, James B. Mitchell, Murali C. Krishna

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Citations (Scopus)


Nitroxyl contrast agents (nitroxyl radicals, also known as nitroxide) are paramagnetic species, which can react with reactive oxygen species (ROS) to lose paramagnetism to be diamagnetic species. The paramagnetic nitroxyl radical forms can be detected by using electron paramagnetic resonance imaging (EPRI), Overhauser MRI (OMRI), or MRI. The time course of in vivo image intensity induced by paramagnetic redox-sensitive contrast agent can give tissue redox information, which is the so-called redox imaging technique. The redox imaging technique employing a blood-brain barrier permeable nitroxyl contrast agent can be applied to analyze the pathophysiological functions in the brain. A brief theory of redox imaging techniques is described, and applications of redox imaging techniques to brain are introduced.

Original languageEnglish
Title of host publicationMagnetic Resonance Neuroimaging
Subtitle of host publicationMethods and Protocols
EditorsMichel Modo, Jelte Bulte
Number of pages23
Publication statusPublished - Dec 1 2010

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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  • Cite this

    Matsumoto, K. I., Hyodo, F., Anzai, K., Utsumi, H., Mitchell, J. B., & Krishna, M. C. (2010). Brain redox imaging. In M. Modo, & J. Bulte (Eds.), Magnetic Resonance Neuroimaging: Methods and Protocols (pp. 397-419). (Methods in Molecular Biology; Vol. 711).