Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice

Mitsuru Tanaka; Hayato Kiyohara; Atsuko Yoshino; Akihiro Nakano; Fuyuko Takata; Shinya Dohgu; Yasufumi Kataoka; Toshiro Matsui

doi:10.1038/s41538-020-0067-3

Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide_25-35-induced memory impairment in mice

Mitsuru Tanaka, Hayato Kiyohara, Atsuko Yoshino, Akihiro Nakano, Fuyuko Takata, Shinya Dohgu, Yasufumi Kataoka, Toshiro Matsui

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In this study, experiments on amyloid β peptide_25-35-induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.

Original language	English
Article number	7
Journal	npj Science of Food
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/s41538-020-0067-3
Publication status	Published - Dec 1 2020

All Science Journal Classification (ASJC) codes

Food Science
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41538-020-0067-3

Cite this

@article{74ab3cc0c0d546fb9bd768e27064e0a2,

title = "Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice",

abstract = "In this study, experiments on amyloid β peptide25-35-induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.",

author = "Mitsuru Tanaka and Hayato Kiyohara and Atsuko Yoshino and Akihiro Nakano and Fuyuko Takata and Shinya Dohgu and Yasufumi Kataoka and Toshiro Matsui",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s41538-020-0067-3",

language = "English",

volume = "4",

journal = "npj Science of Food",

issn = "2396-8370",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice

AU - Tanaka, Mitsuru

AU - Kiyohara, Hayato

AU - Yoshino, Atsuko

AU - Nakano, Akihiro

AU - Takata, Fuyuko

AU - Dohgu, Shinya

AU - Kataoka, Yasufumi

AU - Matsui, Toshiro

PY - 2020/12/1

Y1 - 2020/12/1

N2 - In this study, experiments on amyloid β peptide25-35-induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.

AB - In this study, experiments on amyloid β peptide25-35-induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.

UR - http://www.scopus.com/inward/record.url?scp=85084093947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85084093947&partnerID=8YFLogxK

U2 - 10.1038/s41538-020-0067-3

DO - 10.1038/s41538-020-0067-3

M3 - Article

AN - SCOPUS:85084093947

SN - 2396-8370

VL - 4

JO - npj Science of Food

JF - npj Science of Food

IS - 1

M1 - 7

ER -