Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1

Hiroaki Niiro, Edward A. Clark

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-κB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct conduit regulating either only proliferation (Bam32) or both the proliferation and survival of B cells (Carma1).

Original languageEnglish
Pages (from-to)637-640
Number of pages4
JournalImmunity
Volume19
Issue number5
DOIs
Publication statusPublished - Nov 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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