TY - JOUR
T1 - BRCAness Combined With a Family History of Cancer Is Associated With a Poor Prognosis for Breast Cancer Patients With a High Risk of BRCA Mutations
AU - Mori, Hitomi
AU - Kubo, Makoto
AU - Kai, Masaya
AU - Velasquez, Vittoria Vanessa
AU - Kurata, Kanako
AU - Yamada, Mai
AU - Okido, Masayuki
AU - Kuroki, Syoji
AU - Oda, Yoshinao
AU - Nakamura, Masafumi
N1 - Funding Information:
The authors thank Dr Junji Kishimoto of the Center for Clinical and Translational Research at Kyushu University Hospital, Fukuoka, Japan, for his assistance with the statistical analyses of our study, Hiroshi Fujii for technical assistance, and Yasuhiro Shimoda and Arata Takahashi for performing the MLPA reactions. The authors received a Young Encouragement Award supported by the 41st Annual Meeting of the Japanese Society for Genetic Counseling, 2017. This work was supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (grant 20591550) and JSPS KAKENHI Grant-in-Aid for JSPS Research Fellow (grant 18J20301).
Funding Information:
The authors thank Dr Junji Kishimoto of the Center for Clinical and Translational Research at Kyushu University Hospital, Fukuoka, Japan, for his assistance with the statistical analyses of our study, Hiroshi Fujii for technical assistance, and Yasuhiro Shimoda and Arata Takahashi for performing the MLPA reactions. The authors received a Young Encouragement Award supported by the 41st Annual Meeting of the Japanese Society for Genetic Counseling, 2017. This work was supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (grant 20591550) and JSPS KAKENHI Grant-in-Aid for JSPS Research Fellow (grant 18J20301).
Publisher Copyright:
© 2018 The Authors
PY - 2018/10
Y1 - 2018/10
N2 - We assessed BRCAness as a characteristic of BRCA-mutated breast cancer. We investigated 124 breast cancer patients with a high risk of BRCA mutations, who had early-onset or triple-negative breast cancer. No correlation was found between BRCAness and family history. However, those with a BRCAness tumor and a positive family history had a significantly worse prognosis, which could be of use in predicting the prognosis. Background: The inexpensive prediction of the characteristics of BRCA-mutated breast cancer as “BRCAness” using the somatic cells of patients with breast cancer could be useful for developing a therapeutic strategy. Our objective was to correlate BRCAness with the clinicopathologic features, including a family history (FH) of cancer, in breast cancer patients with a high risk of BRCA mutations. Patients and Methods: The present study included 124 patients, including 55 with early-onset and 77 with triple-negative breast cancer, who had undergone resection at Kyushu University Hospital from 2005 to 2014. Early-onset breast cancer is defined as an onset in patients aged ≤ 40 years. BRCAness was performed using multiple ligation-dependent probe amplification. The patients’ FH of cancer was surveyed from first- to third-degree relatives. Results: Of the 124 patients, the multiple ligation-dependent probe amplification assay results indicated that 59 tumors (47.6%) had BRCAness and 27 patients (21.8%) had a positive FH for cancer. The patients with BRCAness experienced significantly shorter recurrence-free survival (RFS) and overall survival (OS) compared with those without. Patients with FH had shorter RFS and OS compared to those without BRCAness. The patients were divided into those with and without BRCAness and those with and without a positive FH. The BRCAness with FH subgroup experienced significantly shorter RFS and OS. Multivariate analysis revealed that BRCAness and a positive FH were independent negative prognostic factors. Conclusion: Our findings suggest that BRCAness tumors with a positive FH of cancer were associated with a poor prognosis in the BRCA-mutation high-risk group. We propose that BRCAness and a positive FH will serve to predict patients’ prognosis.
AB - We assessed BRCAness as a characteristic of BRCA-mutated breast cancer. We investigated 124 breast cancer patients with a high risk of BRCA mutations, who had early-onset or triple-negative breast cancer. No correlation was found between BRCAness and family history. However, those with a BRCAness tumor and a positive family history had a significantly worse prognosis, which could be of use in predicting the prognosis. Background: The inexpensive prediction of the characteristics of BRCA-mutated breast cancer as “BRCAness” using the somatic cells of patients with breast cancer could be useful for developing a therapeutic strategy. Our objective was to correlate BRCAness with the clinicopathologic features, including a family history (FH) of cancer, in breast cancer patients with a high risk of BRCA mutations. Patients and Methods: The present study included 124 patients, including 55 with early-onset and 77 with triple-negative breast cancer, who had undergone resection at Kyushu University Hospital from 2005 to 2014. Early-onset breast cancer is defined as an onset in patients aged ≤ 40 years. BRCAness was performed using multiple ligation-dependent probe amplification. The patients’ FH of cancer was surveyed from first- to third-degree relatives. Results: Of the 124 patients, the multiple ligation-dependent probe amplification assay results indicated that 59 tumors (47.6%) had BRCAness and 27 patients (21.8%) had a positive FH for cancer. The patients with BRCAness experienced significantly shorter recurrence-free survival (RFS) and overall survival (OS) compared with those without. Patients with FH had shorter RFS and OS compared to those without BRCAness. The patients were divided into those with and without BRCAness and those with and without a positive FH. The BRCAness with FH subgroup experienced significantly shorter RFS and OS. Multivariate analysis revealed that BRCAness and a positive FH were independent negative prognostic factors. Conclusion: Our findings suggest that BRCAness tumors with a positive FH of cancer were associated with a poor prognosis in the BRCA-mutation high-risk group. We propose that BRCAness and a positive FH will serve to predict patients’ prognosis.
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U2 - 10.1016/j.clbc.2018.05.008
DO - 10.1016/j.clbc.2018.05.008
M3 - Article
C2 - 29941390
AN - SCOPUS:85048879966
VL - 18
SP - e1217-e1227
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
SN - 1526-8209
IS - 5
ER -
