Breastfeeding and atopic eczema in Japanese infants: The Osaka Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Satoshi Sasaki, Chikako Kiyohara, Yukihiro Ohya, Wakaba Fukushima, Tetsuji Yokoyama, Yoshio Hirota

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Epidemiological studies associated with breastfeeding have provided conflicting results about whether it is preventive or a risk factor for atopic eczema in children. The current prospective study investigated the relationship between breastfeeding and the risk of atopic eczema in Japan. A birth cohort of 763 infants was followed. The first survey during pregnancy and the second survey between 2 and 9 months postpartum collected information on potential confounding factors and atopic eczema status. Data on breastfeeding and symptoms of atopic eczema were obtained from questionnaires in the third survey from 16 to 24 months postpartum. The following variables were a priori selected as potential confounders: maternal age, maternal and paternal history of asthma, atopic eczema, and allergic rhinitis, indoor domestic pets (cats, dogs, birds, or hamsters), family income, maternal and paternal education, maternal smoking during pregnancy, baby's sex, baby's birth weight, baby's older siblings, household smoking in the same room as the infant, and time of delivery before the third survey. In the third survey, 142 infants (18.6%) were revealed to have developed atopic eczema based on criteria of the International Study of Asthma and Allergies in Childhood. In an overall analysis, neither exclusive nor partial breastfeeding was significantly related to the risk of atopic eczema. After excluding 64 infants identified with suspected atopic eczema in the second survey, both exclusive breastfeeding for 4 months or more and partial breastfeeding for 6 months or more were independently associated with an increased risk of atopic eczema only among infants with no parental history of allergic disorders [multivariate odds ratios were 2.41 (95% confidence interval, 1.10-5.55) and 3.39 (95% confidence interval, 1.20-12.36), respectively]. The authors found that, overall, neither exclusive nor partial breastfeeding had a strong impact on the risk of atopic eczema. However, a parental allergic history may affect the risk.

Original languageEnglish
Pages (from-to)234-241
Number of pages8
JournalPediatric Allergy and Immunology
Volume20
Issue number3
DOIs
Publication statusPublished - May 1 2009

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Atopic Dermatitis
Breast Feeding
Mothers
Postpartum Period
Asthma
Smoking
Maternal Health
Child Health
Confidence Intervals
Pregnancy
Pets
Maternal Age
Surveys and Questionnaires
Birth Weight
Cricetinae
Birds
Siblings
Epidemiologic Studies
Japan
Hypersensitivity

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

Cite this

Breastfeeding and atopic eczema in Japanese infants : The Osaka Maternal and Child Health Study. / Miyake, Yoshihiro; Tanaka, Keiko; Sasaki, Satoshi; Kiyohara, Chikako; Ohya, Yukihiro; Fukushima, Wakaba; Yokoyama, Tetsuji; Hirota, Yoshio.

In: Pediatric Allergy and Immunology, Vol. 20, No. 3, 01.05.2009, p. 234-241.

Research output: Contribution to journalArticle

Miyake, Yoshihiro ; Tanaka, Keiko ; Sasaki, Satoshi ; Kiyohara, Chikako ; Ohya, Yukihiro ; Fukushima, Wakaba ; Yokoyama, Tetsuji ; Hirota, Yoshio. / Breastfeeding and atopic eczema in Japanese infants : The Osaka Maternal and Child Health Study. In: Pediatric Allergy and Immunology. 2009 ; Vol. 20, No. 3. pp. 234-241.
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