Brief parenteral nutrition accelerates weight gain, head growth even in healthy VLBWs

Naho Morisaki, Mandy B. Belfort, Marie C. McCormick, Rintaro Mori, Hisashi Noma, Satoshi Kusuda, Masanori Fujimura, M. Fujimura, S. Kusuda, S. Hattori, A. Noro, T. Amizuka, S. Chida, R. Takahashi, H. Arai, T. Imamura, N. Ujiie, Y. Miyazono, J. Shimizu, H. SuzumuraY. Kono, M. Shimizu, T. Kunikata, T. Fujiu, H. Sato, T. Kondo, T. Watanabe, M. Aizawa, A. Uchiyama, M. Makimoto, J. Hoshi, H. Yoda, Y. Kawakami, N. Ishii, Y. Ito, H. Itani, K. Seki, M. Nomura, M. Nowatari, A. Nemoto, O. Nagata, Y. Nagayama, T. Nakamura, M. Okada, S. Nakata, E. Shimazaki, T. Yoda, T. Hutatani, Y. Ueno, K. Iwai, Y. Nakazawa, S. Oki, C. Suzuki, M. Bonno, Y. Kawano, K. Nakamura, N. Mitsufuji, J. Shiraishi, H. Ichiba, H. Minami, H. Wada, A. Ohashi, K. Sumi, Y. Takahashi, T. Okutani, S. Yoshimoto, I. Nagata, E. Kato, S. Watabe, M. Kageyama, R. Fukuhara, M. Hayashitani, K. Hasegawa, A. Ohta, T. Kuboi, S. Akiyoshi, K. Kikkawa, T. Saijo, S. Shimokawa, N. Matsumoto, H. Kanda, E. Oota, G. Kanda, M. Ochiai, M. Aoki, Y. Kondo, M. Iwai, K. Iida, T. Ikenoue, S. Ibara, M. Kohama

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Whether parenteral nutrition benefits growth of very low birth weight (VLBW) preterm infants in the setting of rapid enteral feeding advancement is unclear. Our aim was to examine this issue using data from Japan, where enteral feeding typically advances at a rapid rate. Methods: We studied 4005 hospitalized VLBW, very preterm (23-32 weeks' gestation) infants who reached full enteral feeding (100 ml/kg/day) by day 14, from 75 institutions in the Neonatal Research Network Japan (2003-2007). Main outcomes were weight gain, head growth, and extra-uterine growth restriction (EUGR, measurement <10th percentile for postmenstrual age) at discharge. Results: 40% of infants received parenteral nutrition. Adjusting for maternal, infant, and institutional characteristics, infants who received parenteral nutrition had greater weight gain [0.09 standard deviation (SD), 95% CI: 0.02, 0.16] and head growth (0.16 SD, 95% CI: 0.05, 0.28); lower odds of EUGR by head circumference (OR 0.66, 95% CI: 0.49, 0.88). No statistically significant difference was seen in the proportion of infants with EUGR at discharge. SGA infants and infants who took more than a week until full feeding had larger estimates. Discussion: Even in infants who are able to establish enteral nutrition within 2 weeks, deprivation of parenteral nutrition in the first weeks of life could lead to under nutrition, but infants who reached full feeding within one week benefit least. It is important to predict which infants are likely or not likely to advance on enteral feedings within a week and balance enteral and parenteral nutrition for these infants.

Original languageEnglish
Article numbere88392
JournalPloS one
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 19 2014

Fingerprint

Parenteral Nutrition
enteral feeding
parenteral feeding
Nutrition
Weight Gain
Head
weight gain
Enteral Nutrition
Growth
low birth weight
Japan
infant nutrition
Very Low Birth Weight Infant
head circumference
malnutrition
pregnancy
Premature Infants
Mothers
Pregnancy

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Morisaki, N., Belfort, M. B., McCormick, M. C., Mori, R., Noma, H., Kusuda, S., ... Kohama, M. (2014). Brief parenteral nutrition accelerates weight gain, head growth even in healthy VLBWs. PloS one, 9(2), [e88392]. https://doi.org/10.1371/journal.pone.0088392

Brief parenteral nutrition accelerates weight gain, head growth even in healthy VLBWs. / Morisaki, Naho; Belfort, Mandy B.; McCormick, Marie C.; Mori, Rintaro; Noma, Hisashi; Kusuda, Satoshi; Fujimura, Masanori; Fujimura, M.; Kusuda, S.; Hattori, S.; Noro, A.; Amizuka, T.; Chida, S.; Takahashi, R.; Arai, H.; Imamura, T.; Ujiie, N.; Miyazono, Y.; Shimizu, J.; Suzumura, H.; Kono, Y.; Shimizu, M.; Kunikata, T.; Fujiu, T.; Sato, H.; Kondo, T.; Watanabe, T.; Aizawa, M.; Uchiyama, A.; Makimoto, M.; Hoshi, J.; Yoda, H.; Kawakami, Y.; Ishii, N.; Ito, Y.; Itani, H.; Seki, K.; Nomura, M.; Nowatari, M.; Nemoto, A.; Nagata, O.; Nagayama, Y.; Nakamura, T.; Okada, M.; Nakata, S.; Shimazaki, E.; Yoda, T.; Hutatani, T.; Ueno, Y.; Iwai, K.; Nakazawa, Y.; Oki, S.; Suzuki, C.; Bonno, M.; Kawano, Y.; Nakamura, K.; Mitsufuji, N.; Shiraishi, J.; Ichiba, H.; Minami, H.; Wada, H.; Ohashi, A.; Sumi, K.; Takahashi, Y.; Okutani, T.; Yoshimoto, S.; Nagata, I.; Kato, E.; Watabe, S.; Kageyama, M.; Fukuhara, R.; Hayashitani, M.; Hasegawa, K.; Ohta, A.; Kuboi, T.; Akiyoshi, S.; Kikkawa, K.; Saijo, T.; Shimokawa, S.; Matsumoto, N.; Kanda, H.; Oota, E.; Kanda, G.; Ochiai, M.; Aoki, M.; Kondo, Y.; Iwai, M.; Iida, K.; Ikenoue, T.; Ibara, S.; Kohama, M.

In: PloS one, Vol. 9, No. 2, e88392, 19.02.2014.

Research output: Contribution to journalArticle

Morisaki, N, Belfort, MB, McCormick, MC, Mori, R, Noma, H, Kusuda, S, Fujimura, M, Fujimura, M, Kusuda, S, Hattori, S, Noro, A, Amizuka, T, Chida, S, Takahashi, R, Arai, H, Imamura, T, Ujiie, N, Miyazono, Y, Shimizu, J, Suzumura, H, Kono, Y, Shimizu, M, Kunikata, T, Fujiu, T, Sato, H, Kondo, T, Watanabe, T, Aizawa, M, Uchiyama, A, Makimoto, M, Hoshi, J, Yoda, H, Kawakami, Y, Ishii, N, Ito, Y, Itani, H, Seki, K, Nomura, M, Nowatari, M, Nemoto, A, Nagata, O, Nagayama, Y, Nakamura, T, Okada, M, Nakata, S, Shimazaki, E, Yoda, T, Hutatani, T, Ueno, Y, Iwai, K, Nakazawa, Y, Oki, S, Suzuki, C, Bonno, M, Kawano, Y, Nakamura, K, Mitsufuji, N, Shiraishi, J, Ichiba, H, Minami, H, Wada, H, Ohashi, A, Sumi, K, Takahashi, Y, Okutani, T, Yoshimoto, S, Nagata, I, Kato, E, Watabe, S, Kageyama, M, Fukuhara, R, Hayashitani, M, Hasegawa, K, Ohta, A, Kuboi, T, Akiyoshi, S, Kikkawa, K, Saijo, T, Shimokawa, S, Matsumoto, N, Kanda, H, Oota, E, Kanda, G, Ochiai, M, Aoki, M, Kondo, Y, Iwai, M, Iida, K, Ikenoue, T, Ibara, S & Kohama, M 2014, 'Brief parenteral nutrition accelerates weight gain, head growth even in healthy VLBWs', PloS one, vol. 9, no. 2, e88392. https://doi.org/10.1371/journal.pone.0088392
Morisaki N, Belfort MB, McCormick MC, Mori R, Noma H, Kusuda S et al. Brief parenteral nutrition accelerates weight gain, head growth even in healthy VLBWs. PloS one. 2014 Feb 19;9(2). e88392. https://doi.org/10.1371/journal.pone.0088392
Morisaki, Naho ; Belfort, Mandy B. ; McCormick, Marie C. ; Mori, Rintaro ; Noma, Hisashi ; Kusuda, Satoshi ; Fujimura, Masanori ; Fujimura, M. ; Kusuda, S. ; Hattori, S. ; Noro, A. ; Amizuka, T. ; Chida, S. ; Takahashi, R. ; Arai, H. ; Imamura, T. ; Ujiie, N. ; Miyazono, Y. ; Shimizu, J. ; Suzumura, H. ; Kono, Y. ; Shimizu, M. ; Kunikata, T. ; Fujiu, T. ; Sato, H. ; Kondo, T. ; Watanabe, T. ; Aizawa, M. ; Uchiyama, A. ; Makimoto, M. ; Hoshi, J. ; Yoda, H. ; Kawakami, Y. ; Ishii, N. ; Ito, Y. ; Itani, H. ; Seki, K. ; Nomura, M. ; Nowatari, M. ; Nemoto, A. ; Nagata, O. ; Nagayama, Y. ; Nakamura, T. ; Okada, M. ; Nakata, S. ; Shimazaki, E. ; Yoda, T. ; Hutatani, T. ; Ueno, Y. ; Iwai, K. ; Nakazawa, Y. ; Oki, S. ; Suzuki, C. ; Bonno, M. ; Kawano, Y. ; Nakamura, K. ; Mitsufuji, N. ; Shiraishi, J. ; Ichiba, H. ; Minami, H. ; Wada, H. ; Ohashi, A. ; Sumi, K. ; Takahashi, Y. ; Okutani, T. ; Yoshimoto, S. ; Nagata, I. ; Kato, E. ; Watabe, S. ; Kageyama, M. ; Fukuhara, R. ; Hayashitani, M. ; Hasegawa, K. ; Ohta, A. ; Kuboi, T. ; Akiyoshi, S. ; Kikkawa, K. ; Saijo, T. ; Shimokawa, S. ; Matsumoto, N. ; Kanda, H. ; Oota, E. ; Kanda, G. ; Ochiai, M. ; Aoki, M. ; Kondo, Y. ; Iwai, M. ; Iida, K. ; Ikenoue, T. ; Ibara, S. ; Kohama, M. / Brief parenteral nutrition accelerates weight gain, head growth even in healthy VLBWs. In: PloS one. 2014 ; Vol. 9, No. 2.
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abstract = "Introduction: Whether parenteral nutrition benefits growth of very low birth weight (VLBW) preterm infants in the setting of rapid enteral feeding advancement is unclear. Our aim was to examine this issue using data from Japan, where enteral feeding typically advances at a rapid rate. Methods: We studied 4005 hospitalized VLBW, very preterm (23-32 weeks' gestation) infants who reached full enteral feeding (100 ml/kg/day) by day 14, from 75 institutions in the Neonatal Research Network Japan (2003-2007). Main outcomes were weight gain, head growth, and extra-uterine growth restriction (EUGR, measurement <10th percentile for postmenstrual age) at discharge. Results: 40{\%} of infants received parenteral nutrition. Adjusting for maternal, infant, and institutional characteristics, infants who received parenteral nutrition had greater weight gain [0.09 standard deviation (SD), 95{\%} CI: 0.02, 0.16] and head growth (0.16 SD, 95{\%} CI: 0.05, 0.28); lower odds of EUGR by head circumference (OR 0.66, 95{\%} CI: 0.49, 0.88). No statistically significant difference was seen in the proportion of infants with EUGR at discharge. SGA infants and infants who took more than a week until full feeding had larger estimates. Discussion: Even in infants who are able to establish enteral nutrition within 2 weeks, deprivation of parenteral nutrition in the first weeks of life could lead to under nutrition, but infants who reached full feeding within one week benefit least. It is important to predict which infants are likely or not likely to advance on enteral feedings within a week and balance enteral and parenteral nutrition for these infants.",
author = "Naho Morisaki and Belfort, {Mandy B.} and McCormick, {Marie C.} and Rintaro Mori and Hisashi Noma and Satoshi Kusuda and Masanori Fujimura and M. Fujimura and S. Kusuda and S. Hattori and A. Noro and T. Amizuka and S. Chida and R. Takahashi and H. Arai and T. Imamura and N. Ujiie and Y. Miyazono and J. Shimizu and H. Suzumura and Y. Kono and M. Shimizu and T. Kunikata and T. Fujiu and H. Sato and T. Kondo and T. Watanabe and M. Aizawa and A. Uchiyama and M. Makimoto and J. Hoshi and H. Yoda and Y. Kawakami and N. Ishii and Y. Ito and H. Itani and K. Seki and M. Nomura and M. Nowatari and A. Nemoto and O. Nagata and Y. Nagayama and T. Nakamura and M. Okada and S. Nakata and E. Shimazaki and T. Yoda and T. Hutatani and Y. Ueno and K. Iwai and Y. Nakazawa and S. Oki and C. Suzuki and M. Bonno and Y. Kawano and K. Nakamura and N. Mitsufuji and J. Shiraishi and H. Ichiba and H. Minami and H. Wada and A. Ohashi and K. Sumi and Y. Takahashi and T. Okutani and S. Yoshimoto and I. Nagata and E. Kato and S. Watabe and M. Kageyama and R. Fukuhara and M. Hayashitani and K. Hasegawa and A. Ohta and T. Kuboi and S. Akiyoshi and K. Kikkawa and T. Saijo and S. Shimokawa and N. Matsumoto and H. Kanda and E. Oota and G. Kanda and M. Ochiai and M. Aoki and Y. Kondo and M. Iwai and K. Iida and T. Ikenoue and S. Ibara and M. Kohama",
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T1 - Brief parenteral nutrition accelerates weight gain, head growth even in healthy VLBWs

AU - Morisaki, Naho

AU - Belfort, Mandy B.

AU - McCormick, Marie C.

AU - Mori, Rintaro

AU - Noma, Hisashi

AU - Kusuda, Satoshi

AU - Fujimura, Masanori

AU - Fujimura, M.

AU - Kusuda, S.

AU - Hattori, S.

AU - Noro, A.

AU - Amizuka, T.

AU - Chida, S.

AU - Takahashi, R.

AU - Arai, H.

AU - Imamura, T.

AU - Ujiie, N.

AU - Miyazono, Y.

AU - Shimizu, J.

AU - Suzumura, H.

AU - Kono, Y.

AU - Shimizu, M.

AU - Kunikata, T.

AU - Fujiu, T.

AU - Sato, H.

AU - Kondo, T.

AU - Watanabe, T.

AU - Aizawa, M.

AU - Uchiyama, A.

AU - Makimoto, M.

AU - Hoshi, J.

AU - Yoda, H.

AU - Kawakami, Y.

AU - Ishii, N.

AU - Ito, Y.

AU - Itani, H.

AU - Seki, K.

AU - Nomura, M.

AU - Nowatari, M.

AU - Nemoto, A.

AU - Nagata, O.

AU - Nagayama, Y.

AU - Nakamura, T.

AU - Okada, M.

AU - Nakata, S.

AU - Shimazaki, E.

AU - Yoda, T.

AU - Hutatani, T.

AU - Ueno, Y.

AU - Iwai, K.

AU - Nakazawa, Y.

AU - Oki, S.

AU - Suzuki, C.

AU - Bonno, M.

AU - Kawano, Y.

AU - Nakamura, K.

AU - Mitsufuji, N.

AU - Shiraishi, J.

AU - Ichiba, H.

AU - Minami, H.

AU - Wada, H.

AU - Ohashi, A.

AU - Sumi, K.

AU - Takahashi, Y.

AU - Okutani, T.

AU - Yoshimoto, S.

AU - Nagata, I.

AU - Kato, E.

AU - Watabe, S.

AU - Kageyama, M.

AU - Fukuhara, R.

AU - Hayashitani, M.

AU - Hasegawa, K.

AU - Ohta, A.

AU - Kuboi, T.

AU - Akiyoshi, S.

AU - Kikkawa, K.

AU - Saijo, T.

AU - Shimokawa, S.

AU - Matsumoto, N.

AU - Kanda, H.

AU - Oota, E.

AU - Kanda, G.

AU - Ochiai, M.

AU - Aoki, M.

AU - Kondo, Y.

AU - Iwai, M.

AU - Iida, K.

AU - Ikenoue, T.

AU - Ibara, S.

AU - Kohama, M.

PY - 2014/2/19

Y1 - 2014/2/19

N2 - Introduction: Whether parenteral nutrition benefits growth of very low birth weight (VLBW) preterm infants in the setting of rapid enteral feeding advancement is unclear. Our aim was to examine this issue using data from Japan, where enteral feeding typically advances at a rapid rate. Methods: We studied 4005 hospitalized VLBW, very preterm (23-32 weeks' gestation) infants who reached full enteral feeding (100 ml/kg/day) by day 14, from 75 institutions in the Neonatal Research Network Japan (2003-2007). Main outcomes were weight gain, head growth, and extra-uterine growth restriction (EUGR, measurement <10th percentile for postmenstrual age) at discharge. Results: 40% of infants received parenteral nutrition. Adjusting for maternal, infant, and institutional characteristics, infants who received parenteral nutrition had greater weight gain [0.09 standard deviation (SD), 95% CI: 0.02, 0.16] and head growth (0.16 SD, 95% CI: 0.05, 0.28); lower odds of EUGR by head circumference (OR 0.66, 95% CI: 0.49, 0.88). No statistically significant difference was seen in the proportion of infants with EUGR at discharge. SGA infants and infants who took more than a week until full feeding had larger estimates. Discussion: Even in infants who are able to establish enteral nutrition within 2 weeks, deprivation of parenteral nutrition in the first weeks of life could lead to under nutrition, but infants who reached full feeding within one week benefit least. It is important to predict which infants are likely or not likely to advance on enteral feedings within a week and balance enteral and parenteral nutrition for these infants.

AB - Introduction: Whether parenteral nutrition benefits growth of very low birth weight (VLBW) preterm infants in the setting of rapid enteral feeding advancement is unclear. Our aim was to examine this issue using data from Japan, where enteral feeding typically advances at a rapid rate. Methods: We studied 4005 hospitalized VLBW, very preterm (23-32 weeks' gestation) infants who reached full enteral feeding (100 ml/kg/day) by day 14, from 75 institutions in the Neonatal Research Network Japan (2003-2007). Main outcomes were weight gain, head growth, and extra-uterine growth restriction (EUGR, measurement <10th percentile for postmenstrual age) at discharge. Results: 40% of infants received parenteral nutrition. Adjusting for maternal, infant, and institutional characteristics, infants who received parenteral nutrition had greater weight gain [0.09 standard deviation (SD), 95% CI: 0.02, 0.16] and head growth (0.16 SD, 95% CI: 0.05, 0.28); lower odds of EUGR by head circumference (OR 0.66, 95% CI: 0.49, 0.88). No statistically significant difference was seen in the proportion of infants with EUGR at discharge. SGA infants and infants who took more than a week until full feeding had larger estimates. Discussion: Even in infants who are able to establish enteral nutrition within 2 weeks, deprivation of parenteral nutrition in the first weeks of life could lead to under nutrition, but infants who reached full feeding within one week benefit least. It is important to predict which infants are likely or not likely to advance on enteral feedings within a week and balance enteral and parenteral nutrition for these infants.

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