Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)

Sei Joon Jeong, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Shunsuke F. Mawatari

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

A new antiangiogenic compound, bryoanthrathiophene (1), together with two known compounds, 5,7- dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra[1,9-bc]thiophene (2) and 1,8-dihydroxyanthraquinone (3), was isolated from the bryozoan Watersipora subtorquata (d'Orbigny, 1852) using bioassay-guided fractionation methods. Among them, bryoanthrathiophene (1) exhibited the most potent antiangiogenic activity on BAEC (bovine aorta endothelial cell) proliferation.

Original languageEnglish
Pages (from-to)1344-1345
Number of pages2
JournalJournal of Natural Products
Volume65
Issue number9
DOIs
Publication statusPublished - Sep 1 2002

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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