Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)

Sei Joon Jeong, Ryuichi Higuchi, Tomofumi Miyamoto, Mayumi Ono, Michihiko Kuwano, Shunsuke F. Mawatari

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A new antiangiogenic compound, bryoanthrathiophene (1), together with two known compounds, 5,7- dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra[1,9-bc]thiophene (2) and 1,8-dihydroxyanthraquinone (3), was isolated from the bryozoan Watersipora subtorquata (d'Orbigny, 1852) using bioassay-guided fractionation methods. Among them, bryoanthrathiophene (1) exhibited the most potent antiangiogenic activity on BAEC (bovine aorta endothelial cell) proliferation.

Original languageEnglish
Pages (from-to)1344-1345
Number of pages2
JournalJournal of Natural Products
Volume65
Issue number9
DOIs
Publication statusPublished - Sep 1 2002

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Bioassay
Endothelial cells
Cell proliferation
Fractionation
Biological Assay
Aorta
Endothelial Cells
Cell Proliferation
bryoanthrathiophene
5,7-dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra(1,9-bc)thiophene
danthron

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852). / Jeong, Sei Joon; Higuchi, Ryuichi; Miyamoto, Tomofumi; Ono, Mayumi; Kuwano, Michihiko; Mawatari, Shunsuke F.

In: Journal of Natural Products, Vol. 65, No. 9, 01.09.2002, p. 1344-1345.

Research output: Contribution to journalArticle

Jeong, Sei Joon ; Higuchi, Ryuichi ; Miyamoto, Tomofumi ; Ono, Mayumi ; Kuwano, Michihiko ; Mawatari, Shunsuke F. / Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852). In: Journal of Natural Products. 2002 ; Vol. 65, No. 9. pp. 1344-1345.
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