Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes

Shinsuke Yasukawa, Teruki Dainichi, Hisashi Kokuba, Yoichi Moroi, Kazunori Urabe, Takashi Hashimoto, Masutaka Furue

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Psoriasis vulgaris is occasionally accompanied by autoimmune bullous diseases, but the opposite is very rare. We document here the first reported case of generalized pustular psoriasis that appeared during steroid therapy for bullous pemphigoid. The serum cytokine levels and the results of an immunohistochernical study over the disease course suggest that the immunological state was consistent with a shift from Th2-dominance to Th1-dominance. IL-17-producing cells appeared in the skin lesions when each disease was most exacerbated and disappeared after remission. Thus, the present case demonstrated a dynamic immunological state in which the appearances of Th1 and Th2 as well as Th17 varied during the course of the disease.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalEuropean Journal of Dermatology
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

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Bullous Pemphigoid
Psoriasis
Interleukin-17
Autoimmune Diseases
Steroids
Cytokines
Skin
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes. / Yasukawa, Shinsuke; Dainichi, Teruki; Kokuba, Hisashi; Moroi, Yoichi; Urabe, Kazunori; Hashimoto, Takashi; Furue, Masutaka.

In: European Journal of Dermatology, Vol. 19, No. 1, 01.01.2009, p. 69-71.

Research output: Contribution to journalArticle

Yasukawa, Shinsuke ; Dainichi, Teruki ; Kokuba, Hisashi ; Moroi, Yoichi ; Urabe, Kazunori ; Hashimoto, Takashi ; Furue, Masutaka. / Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes. In: European Journal of Dermatology. 2009 ; Vol. 19, No. 1. pp. 69-71.
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