Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes

Shinsuke Yasukawa, Teruki Dainichi, Hisashi Kokuba, Yoichi Moroi, Kazunori Urabe, Takashi Hashimoto, Masutaka Furue

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14 Citations (Scopus)


Psoriasis vulgaris is occasionally accompanied by autoimmune bullous diseases, but the opposite is very rare. We document here the first reported case of generalized pustular psoriasis that appeared during steroid therapy for bullous pemphigoid. The serum cytokine levels and the results of an immunohistochernical study over the disease course suggest that the immunological state was consistent with a shift from Th2-dominance to Th1-dominance. IL-17-producing cells appeared in the skin lesions when each disease was most exacerbated and disappeared after remission. Thus, the present case demonstrated a dynamic immunological state in which the appearances of Th1 and Th2 as well as Th17 varied during the course of the disease.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalEuropean Journal of Dermatology
Issue number1
Publication statusPublished - Jan 1 2009


All Science Journal Classification (ASJC) codes

  • Dermatology

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