c-erbB-2 expression is predictive for lymphatic spread of clinical gastric carcinoma

Hiroyuki Orita, Yoshihiko Maehara, Yasunori Emi, Yoshihiro Kakeji, Hideo Baba, Daisuke Korenaga, Keizo Sugimachi

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29 Citations (Scopus)

Abstract

Background/Aims: In patients with gastric carcinoma, the prognostic significance of c-erbB-2 oncogene expression was elucidated, but its role in the aggressive behavior of tumors is not clear. Patients and Methods: We asked whether or not c-erbB-2 gene expression, may have predictability with regard to the metastatic potential in 160 patients with gastric carcinoma using a immunohistochemical staining and a multivariate analysis. Results: c-erbB-2 immunoreactivity was observed in 11% (17/160) of tumors. Patients with c-erbB-2 product positive tumors had a significant shorter prognosis (p < 0.05), and were characterized by a high incidence of peritoneal dissemination (41% liver metastasis (18%) and lymph node involvement (94%). In the multivariate logistic analysis revealed that c-erbB-2 expression was a significant risk factor related to lymph node involvement (p < 0.01). Conclusions: Our multivariate analysis revealed that c-erbB-2 expression is linked to the metastatic potential in patients with gastric carcinoma.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalHepato-gastroenterology
Volume44
Issue number13
Publication statusPublished - Mar 11 1997

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Orita, H., Maehara, Y., Emi, Y., Kakeji, Y., Baba, H., Korenaga, D., & Sugimachi, K. (1997). c-erbB-2 expression is predictive for lymphatic spread of clinical gastric carcinoma. Hepato-gastroenterology, 44(13), 294-298.