C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma

Heike Varnholt, Yoshiki Asayama, Shin Ichi Aishima, Ken Ichi Taguchi, Keishi Sugimachi, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The membranous tyrosine kinase receptor c-met and its natural ligand hepatocyte growth factor are prominent mitogens, motogens and morphogens for hepatocytes and many other cell types in vitro as well as in vivo. To clarify the significance of the c-met/hepatocyte growth factor system in the development and spread of combined hepatocellular and cholangiocarcinoma, surgical specimen from 30 patients, consisting of 4 double cancers, 20 combined types and 6 mixed types, were examined immunohistochemically. Immunoreactivity for HGF was significantly correlated with the differentiation degree of cholangiocellular components, being highest in well and moderately differentiated and lowest in poorly differentiated components (p=0.0119). No significant association was observed between expression of c-met or HGF and the presence of liver cirrhosis, vascular invasion, perineural invasion, lymphatic permeation, intrahepatic metastasis or lymph node metastasis. HGF may have an important impact on the differentiation of certain cHCC-CC. Other clinicopathologic factors related to tumor development and spread may not be influenced by c-met or HGF, at least not on the protein level.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalOncology reports
Volume9
Issue number1
Publication statusPublished - Jan 1 2002

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Hepatocyte Growth Factor
Cholangiocarcinoma
Proto-Oncogene Proteins c-met
Neoplasm Metastasis
Mitogens
Liver Cirrhosis
Blood Vessels
Hepatocytes
Neoplasms
Lymph Nodes
Ligands
Proteins
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Varnholt, H., Asayama, Y., Aishima, S. I., Taguchi, K. I., Sugimachi, K., & Tsuneyoshi, M. (2002). C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. Oncology reports, 9(1), 35-41.

C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. / Varnholt, Heike; Asayama, Yoshiki; Aishima, Shin Ichi; Taguchi, Ken Ichi; Sugimachi, Keishi; Tsuneyoshi, Masazumi.

In: Oncology reports, Vol. 9, No. 1, 01.01.2002, p. 35-41.

Research output: Contribution to journalArticle

Varnholt, H, Asayama, Y, Aishima, SI, Taguchi, KI, Sugimachi, K & Tsuneyoshi, M 2002, 'C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma', Oncology reports, vol. 9, no. 1, pp. 35-41.
Varnholt H, Asayama Y, Aishima SI, Taguchi KI, Sugimachi K, Tsuneyoshi M. C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. Oncology reports. 2002 Jan 1;9(1):35-41.
Varnholt, Heike ; Asayama, Yoshiki ; Aishima, Shin Ichi ; Taguchi, Ken Ichi ; Sugimachi, Keishi ; Tsuneyoshi, Masazumi. / C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. In: Oncology reports. 2002 ; Vol. 9, No. 1. pp. 35-41.
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