C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer

Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Tomohiro Kamori, Tetsuro Kawazoe, Yasuhiro Haruta, Yoshiaki Fujimoto, Hiroya Matsuoka, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Qingjiang Hu, Yasuo Tsuda, Koichi Kimura, Kouji Andou, Eiji Oki, Tetsuo Ikeda, Yoshihiko Maehara

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background and Aim: The C-reactive protein (CRP)/albumin (Alb) ratio has been reported as a novel prognostic marker in several cancers. The objective of this study was to investigate the prognostic value of the CRP/Alb ratio in patients who underwent surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC). Methods: Data for 144 patients who underwent surgery for AEG and UGC were reviewed. The CRP/Alb ratio, neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, Glasgow Prognostic Score, and controlling nutritional status score were calculated, and the relationship between these biomarkers and postoperative prognosis was analyzed. Results: The optimal cutoff value of the CRP/Alb ratio was determined to be 0.1. According to the cutoff value of CRP/Alb ratio, patients were divided into two groups (CRP/Alb < 0.1, n = 124; CRP/Alb ≥ 0.1, n = 20). The 5-year recurrence-free survival and overall survival (OS) rates were significantly lower in the patients with the CRP/Alb ratio ≥ 0.1 than in those with the CRP/Alb ratio < 0.1 (recurrence-free survival: 44.9% vs 77.9%, P = 0.0011; OS: 43.4% vs 82.0%, P < 0.0001). In the multivariate analyses, the N-stage, and CRP/Alb ratio ≥ 0.1 were identified as independent predictive factors for OS in patients with AEG and UGC (P = 0.0061 and P = 0.0439, respectively). Conclusions: The CRP/Alb ratio was strongly associated with poor prognosis in patients who underwent surgery for AEG and UGC.

Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

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Esophagogastric Junction
C-Reactive Protein
Stomach Neoplasms
Albumins
Adenocarcinoma
Survival
Recurrence
Nutritional Status
Multivariate Analysis
Survival Rate
Biomarkers

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer. / Kudou, Kensuke; Saeki, Hiroshi; Nakashima, Yuichiro; Kamori, Tomohiro; Kawazoe, Tetsuro; Haruta, Yasuhiro; Fujimoto, Yoshiaki; Matsuoka, Hiroya; Sasaki, Shun; Jogo, Tomoko; Hirose, Kosuke; Hu, Qingjiang; Tsuda, Yasuo; Kimura, Koichi; Andou, Kouji; Oki, Eiji; Ikeda, Tetsuo; Maehara, Yoshihiko.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 34, No. 2, 01.02.2019, p. 355-363.

Research output: Contribution to journalReview article

Kudou, K, Saeki, H, Nakashima, Y, Kamori, T, Kawazoe, T, Haruta, Y, Fujimoto, Y, Matsuoka, H, Sasaki, S, Jogo, T, Hirose, K, Hu, Q, Tsuda, Y, Kimura, K, Andou, K, Oki, E, Ikeda, T & Maehara, Y 2019, 'C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer', Journal of Gastroenterology and Hepatology (Australia), vol. 34, no. 2, pp. 355-363. https://doi.org/10.1111/jgh.14442
Kudou, Kensuke ; Saeki, Hiroshi ; Nakashima, Yuichiro ; Kamori, Tomohiro ; Kawazoe, Tetsuro ; Haruta, Yasuhiro ; Fujimoto, Yoshiaki ; Matsuoka, Hiroya ; Sasaki, Shun ; Jogo, Tomoko ; Hirose, Kosuke ; Hu, Qingjiang ; Tsuda, Yasuo ; Kimura, Koichi ; Andou, Kouji ; Oki, Eiji ; Ikeda, Tetsuo ; Maehara, Yoshihiko. / C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer. In: Journal of Gastroenterology and Hepatology (Australia). 2019 ; Vol. 34, No. 2. pp. 355-363.
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title = "C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer",
abstract = "Background and Aim: The C-reactive protein (CRP)/albumin (Alb) ratio has been reported as a novel prognostic marker in several cancers. The objective of this study was to investigate the prognostic value of the CRP/Alb ratio in patients who underwent surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC). Methods: Data for 144 patients who underwent surgery for AEG and UGC were reviewed. The CRP/Alb ratio, neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, Glasgow Prognostic Score, and controlling nutritional status score were calculated, and the relationship between these biomarkers and postoperative prognosis was analyzed. Results: The optimal cutoff value of the CRP/Alb ratio was determined to be 0.1. According to the cutoff value of CRP/Alb ratio, patients were divided into two groups (CRP/Alb < 0.1, n = 124; CRP/Alb ≥ 0.1, n = 20). The 5-year recurrence-free survival and overall survival (OS) rates were significantly lower in the patients with the CRP/Alb ratio ≥ 0.1 than in those with the CRP/Alb ratio < 0.1 (recurrence-free survival: 44.9{\%} vs 77.9{\%}, P = 0.0011; OS: 43.4{\%} vs 82.0{\%}, P < 0.0001). In the multivariate analyses, the N-stage, and CRP/Alb ratio ≥ 0.1 were identified as independent predictive factors for OS in patients with AEG and UGC (P = 0.0061 and P = 0.0439, respectively). Conclusions: The CRP/Alb ratio was strongly associated with poor prognosis in patients who underwent surgery for AEG and UGC.",
author = "Kensuke Kudou and Hiroshi Saeki and Yuichiro Nakashima and Tomohiro Kamori and Tetsuro Kawazoe and Yasuhiro Haruta and Yoshiaki Fujimoto and Hiroya Matsuoka and Shun Sasaki and Tomoko Jogo and Kosuke Hirose and Qingjiang Hu and Yasuo Tsuda and Koichi Kimura and Kouji Andou and Eiji Oki and Tetsuo Ikeda and Yoshihiko Maehara",
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T1 - C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer

AU - Kudou, Kensuke

AU - Saeki, Hiroshi

AU - Nakashima, Yuichiro

AU - Kamori, Tomohiro

AU - Kawazoe, Tetsuro

AU - Haruta, Yasuhiro

AU - Fujimoto, Yoshiaki

AU - Matsuoka, Hiroya

AU - Sasaki, Shun

AU - Jogo, Tomoko

AU - Hirose, Kosuke

AU - Hu, Qingjiang

AU - Tsuda, Yasuo

AU - Kimura, Koichi

AU - Andou, Kouji

AU - Oki, Eiji

AU - Ikeda, Tetsuo

AU - Maehara, Yoshihiko

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background and Aim: The C-reactive protein (CRP)/albumin (Alb) ratio has been reported as a novel prognostic marker in several cancers. The objective of this study was to investigate the prognostic value of the CRP/Alb ratio in patients who underwent surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC). Methods: Data for 144 patients who underwent surgery for AEG and UGC were reviewed. The CRP/Alb ratio, neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, Glasgow Prognostic Score, and controlling nutritional status score were calculated, and the relationship between these biomarkers and postoperative prognosis was analyzed. Results: The optimal cutoff value of the CRP/Alb ratio was determined to be 0.1. According to the cutoff value of CRP/Alb ratio, patients were divided into two groups (CRP/Alb < 0.1, n = 124; CRP/Alb ≥ 0.1, n = 20). The 5-year recurrence-free survival and overall survival (OS) rates were significantly lower in the patients with the CRP/Alb ratio ≥ 0.1 than in those with the CRP/Alb ratio < 0.1 (recurrence-free survival: 44.9% vs 77.9%, P = 0.0011; OS: 43.4% vs 82.0%, P < 0.0001). In the multivariate analyses, the N-stage, and CRP/Alb ratio ≥ 0.1 were identified as independent predictive factors for OS in patients with AEG and UGC (P = 0.0061 and P = 0.0439, respectively). Conclusions: The CRP/Alb ratio was strongly associated with poor prognosis in patients who underwent surgery for AEG and UGC.

AB - Background and Aim: The C-reactive protein (CRP)/albumin (Alb) ratio has been reported as a novel prognostic marker in several cancers. The objective of this study was to investigate the prognostic value of the CRP/Alb ratio in patients who underwent surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC). Methods: Data for 144 patients who underwent surgery for AEG and UGC were reviewed. The CRP/Alb ratio, neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, Glasgow Prognostic Score, and controlling nutritional status score were calculated, and the relationship between these biomarkers and postoperative prognosis was analyzed. Results: The optimal cutoff value of the CRP/Alb ratio was determined to be 0.1. According to the cutoff value of CRP/Alb ratio, patients were divided into two groups (CRP/Alb < 0.1, n = 124; CRP/Alb ≥ 0.1, n = 20). The 5-year recurrence-free survival and overall survival (OS) rates were significantly lower in the patients with the CRP/Alb ratio ≥ 0.1 than in those with the CRP/Alb ratio < 0.1 (recurrence-free survival: 44.9% vs 77.9%, P = 0.0011; OS: 43.4% vs 82.0%, P < 0.0001). In the multivariate analyses, the N-stage, and CRP/Alb ratio ≥ 0.1 were identified as independent predictive factors for OS in patients with AEG and UGC (P = 0.0061 and P = 0.0439, respectively). Conclusions: The CRP/Alb ratio was strongly associated with poor prognosis in patients who underwent surgery for AEG and UGC.

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