Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and autonomic nervous system

Yoshitaka Hirooka, Kenji Sunagawa

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Calcium channel blockers are widely used for the treatment of hypertension. Although they are effective for their strong vasodilator action, there are concerns regarding related baroreflex-mediated activation of sympathetic nervous system. However, long-acting calcium channel blockers, such as amlodipine, are now known safe for the treatment of hypertension. Furthermore, the new type of calcium channel blockers, such as cilnidipine with N-type calcium channel blocking action, or azelnidipine that has sympatho-inhibitory action with anti-oxidant effect, provide a new insight for the future use of calcium channel blockers.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalClinical calcium
Volume20
Issue number1
Publication statusPublished - Jan 2010

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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