Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and autonomic nervous system

Yoshitaka Hirooka, Kenji Sunagawa

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)

    Abstract

    Calcium channel blockers are widely used for the treatment of hypertension. Although they are effective for their strong vasodilator action, there are concerns regarding related baroreflex-mediated activation of sympathetic nervous system. However, long-acting calcium channel blockers, such as amlodipine, are now known safe for the treatment of hypertension. Furthermore, the new type of calcium channel blockers, such as cilnidipine with N-type calcium channel blocking action, or azelnidipine that has sympatho-inhibitory action with anti-oxidant effect, provide a new insight for the future use of calcium channel blockers.

    Original languageEnglish
    Pages (from-to)32-37
    Number of pages6
    JournalClinical calcium
    Volume20
    Issue number1
    Publication statusPublished - Jan 2010

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

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