Calcium-associated mechanisms in gut pacemaker activity: Interstitial Cajal-like Cells Review Series

Shinsuke Nakayama, Shunichi Kajioka, Kazunori Goto, Miyako Takaki, Hong Nian Liu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Introduction Voltage-operated Ca2+ channels Non-selective cation channels Cl- channels [Ca2+]i oscillations Intracellular Ca2+ release channels ICC-like cells in auxiliary digestive organs A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

Original languageEnglish
Pages (from-to)958-968
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume11
Issue number5
DOIs
Publication statusPublished - Sep 1 2007

Fingerprint

Interstitial Cells of Cajal
Pacemakers
Calcium
Ion Channels
Cations
Cells
Electric potential
Gastrointestinal Tract
Telocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Calcium-associated mechanisms in gut pacemaker activity : Interstitial Cajal-like Cells Review Series. / Nakayama, Shinsuke; Kajioka, Shunichi; Goto, Kazunori; Takaki, Miyako; Liu, Hong Nian.

In: Journal of Cellular and Molecular Medicine, Vol. 11, No. 5, 01.09.2007, p. 958-968.

Research output: Contribution to journalArticle

Nakayama, Shinsuke ; Kajioka, Shunichi ; Goto, Kazunori ; Takaki, Miyako ; Liu, Hong Nian. / Calcium-associated mechanisms in gut pacemaker activity : Interstitial Cajal-like Cells Review Series. In: Journal of Cellular and Molecular Medicine. 2007 ; Vol. 11, No. 5. pp. 958-968.
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