Calcium-associated mechanisms in gut pacemaker activity: Interstitial Cajal-like Cells Review Series

Shinsuke Nakayama; Shunichi Kajioka; Kazunori Goto; Miyako Takaki; Hong Nian Liu

doi:10.1111/j.1582-4934.2007.00107.x

Calcium-associated mechanisms in gut pacemaker activity: Interstitial Cajal-like Cells Review Series

Shinsuke Nakayama, Shunichi Kajioka, Kazunori Goto, Miyako Takaki, Hong Nian Liu

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20 Citations (Scopus)

Abstract

Introduction Voltage-operated Ca²⁺ channels Non-selective cation channels Cl^- channels [Ca²⁺]_i oscillations Intracellular Ca²⁺ release channels ICC-like cells in auxiliary digestive organs A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca²⁺ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca²⁺ oscillations in ICC periodically activate plasmalemmal Ca²⁺-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca²⁺-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

Original language	English
Pages (from-to)	958-968
Number of pages	11
Journal	Journal of Cellular and Molecular Medicine
Volume	11
Issue number	5
DOIs	https://doi.org/10.1111/j.1582-4934.2007.00107.x
Publication status	Published - Sep 2007

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cell Biology

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Nakayama, S., Kajioka, S., Goto, K., Takaki, M., & Liu, H. N. (2007). Calcium-associated mechanisms in gut pacemaker activity: Interstitial Cajal-like Cells Review Series. Journal of Cellular and Molecular Medicine, 11(5), 958-968. https://doi.org/10.1111/j.1582-4934.2007.00107.x

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abstract = "Introduction Voltage-operated Ca2+ channels Non-selective cation channels Cl- channels [Ca2+]i oscillations Intracellular Ca2+ release channels ICC-like cells in auxiliary digestive organs A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.",

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