Calcium-associated mechanisms in gut pacemaker activity: Interstitial Cajal-like Cells Review Series

Shinsuke Nakayama, Shunichi Kajioka, Kazunori Goto, Miyako Takaki, Hong Nian Liu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Introduction Voltage-operated Ca2+ channels Non-selective cation channels Cl- channels [Ca2+]i oscillations Intracellular Ca2+ release channels ICC-like cells in auxiliary digestive organs A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

Original languageEnglish
Pages (from-to)958-968
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume11
Issue number5
DOIs
Publication statusPublished - Sep 2007

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cell Biology

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