TY - JOUR
T1 - Calcium-associated mechanisms in gut pacemaker activity
T2 - Interstitial Cajal-like Cells Review Series
AU - Nakayama, Shinsuke
AU - Kajioka, Shunichi
AU - Goto, Kazunori
AU - Takaki, Miyako
AU - Liu, Hong Nian
PY - 2007/9
Y1 - 2007/9
N2 - Introduction Voltage-operated Ca2+ channels Non-selective cation channels Cl- channels [Ca2+]i oscillations Intracellular Ca2+ release channels ICC-like cells in auxiliary digestive organs A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.
AB - Introduction Voltage-operated Ca2+ channels Non-selective cation channels Cl- channels [Ca2+]i oscillations Intracellular Ca2+ release channels ICC-like cells in auxiliary digestive organs A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.
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U2 - 10.1111/j.1582-4934.2007.00107.x
DO - 10.1111/j.1582-4934.2007.00107.x
M3 - Article
C2 - 17979877
AN - SCOPUS:35648965716
VL - 11
SP - 958
EP - 968
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
SN - 1582-1838
IS - 5
ER -