Calcium-channel antagonists inhibit marble-burying behavior in mice

Nobuaki Egashira, Ryoko Okuno, Moe Abe, Michihiko Matsushita, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Ryoji Nishimura, Yoshiaki Matsumoto, Michihiro Fujiwara

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9 Citations (Scopus)

Abstract

In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalJournal of Pharmacological Sciences
Volume108
Issue number1
DOIs
Publication statusPublished - Oct 6 2008

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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  • Cite this

    Egashira, N., Okuno, R., Abe, M., Matsushita, M., Mishima, K., Iwasaki, K., Oishi, R., Nishimura, R., Matsumoto, Y., & Fujiwara, M. (2008). Calcium-channel antagonists inhibit marble-burying behavior in mice. Journal of Pharmacological Sciences, 108(1), 140-143. https://doi.org/10.1254/jphs.08160SC