Calcium channel in isolated outer hair cells of guinea pig cochlea

T. Nakagwa, S. Kakehata, N. Akaike, S. Komune, T. Takasaka, T. Uemura

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Abstract

The physiological and pharmacological properties of the Ca2+ channel in outer hair cells (OHCs) freshly isolated from guinea pig cochlea were investigated using a whole-cell patch-clamp technique. The Ca2+ current (ICa) was activated from a membrane potential of -20 mV and reached peak value around +20 mV in external solution containing 20 mM Ca2+ at a holding potential of -70 mV. The peak amplitude of ICa increased in a hyperbolic manner with increasing extracellular Ca2+ concentration. The ion selectively was Ba2+ > > Ca2+ ≥Sr2+. It was concluded that the Ca2+ channel in OHCs of guinea pig is of the L-type.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume125
Issue number1
DOIs
Publication statusPublished - Apr 15 1991

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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