Calcium channel in isolated outer hair cells of guinea pig cochlea

T. Nakagwa, S. Kakehata, N. Akaike, S. Komune, T. Takasaka, T. Uemura

Research output: Contribution to journalArticle

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Abstract

The physiological and pharmacological properties of the Ca2+ channel in outer hair cells (OHCs) freshly isolated from guinea pig cochlea were investigated using a whole-cell patch-clamp technique. The Ca2+ current (ICa) was activated from a membrane potential of -20 mV and reached peak value around +20 mV in external solution containing 20 mM Ca2+ at a holding potential of -70 mV. The peak amplitude of ICa increased in a hyperbolic manner with increasing extracellular Ca2+ concentration. The ion selectively was Ba2+ > > Ca2+ ≥Sr2+. It was concluded that the Ca2+ channel in OHCs of guinea pig is of the L-type.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume125
Issue number1
DOIs
Publication statusPublished - Apr 15 1991

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Outer Auditory Hair Cells
Cochlea
Calcium Channels
Guinea Pigs
Patch-Clamp Techniques
Membrane Potentials
Pharmacology
Ions

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nakagwa, T., Kakehata, S., Akaike, N., Komune, S., Takasaka, T., & Uemura, T. (1991). Calcium channel in isolated outer hair cells of guinea pig cochlea. Neuroscience Letters, 125(1), 81-84. https://doi.org/10.1016/0304-3940(91)90136-H

Calcium channel in isolated outer hair cells of guinea pig cochlea. / Nakagwa, T.; Kakehata, S.; Akaike, N.; Komune, S.; Takasaka, T.; Uemura, T.

In: Neuroscience Letters, Vol. 125, No. 1, 15.04.1991, p. 81-84.

Research output: Contribution to journalArticle

Nakagwa, T, Kakehata, S, Akaike, N, Komune, S, Takasaka, T & Uemura, T 1991, 'Calcium channel in isolated outer hair cells of guinea pig cochlea', Neuroscience Letters, vol. 125, no. 1, pp. 81-84. https://doi.org/10.1016/0304-3940(91)90136-H
Nakagwa, T. ; Kakehata, S. ; Akaike, N. ; Komune, S. ; Takasaka, T. ; Uemura, T. / Calcium channel in isolated outer hair cells of guinea pig cochlea. In: Neuroscience Letters. 1991 ; Vol. 125, No. 1. pp. 81-84.
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