Calcium, dairy foods, vitamin D, and colorectal cancer risk: The fukuoka colorectal cancer study

Tetsuya Mizoue, Yasumi Kimura, Kengo Toyomura, Jun Nagano, Suminori Kono, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Yohichi Yasunami, Takafumi Maekawa, Kenji Takenaka, Hitoshi Ichimiya, Nobutoshi Imaizumi

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Epidemiologic evidence supporting a protective role of calcium and vitamin D in colorectal carcinogenesis has been accumulating in Western populations, but it is limited in Asian populations, whose intake of calcium is relatively low. We investigated the association of intakes of these nutrients with colorectal cancer risk in Japanese. Study subjects were participants of a large-scale case-control study in Fukuoka, Japan. Diet was assessed through interview regarding 148 dietary items by showing typical foods or dishes on the display of a personal computer. In a multivariate analysis adjusting for potential confounding variables, calcium intake was significantly, inversely associated with colorectal cancer risk (P for trend = 0.01); the odds ratio for the highest versus lowest quintile of calcium intake was 0.64 (95% confidence interval, 0.45-0.93). Higher levels of dietary vitamin D were significantly associated with decreased risk of colorectal cancer among those who had fewer chances of sunlight exposure at work or in leisure (P for trend = 0.02). A decreased risk of colorectal cancer associated with high calcium intake was observed among those who had higher levels of vitamin D intake or among those who had a greater chance of daily sunlight exposure, but not among those with medium or lower intake of vitamin D or among those with potentially decreased sunlight exposure. These results add to support for a joint action of calcium and vitamin D in the prevention of colorectal carcinogenesis.

Original languageEnglish
Pages (from-to)2800-2807
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 1 2008

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Vitamin D
Colorectal Neoplasms
Calcium
Food
Sunlight
Carcinogenesis
Confounding Factors (Epidemiology)
Leisure Activities
Microcomputers
Population
Case-Control Studies
Japan
Multivariate Analysis
Odds Ratio
Confidence Intervals
Interviews
Diet

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Calcium, dairy foods, vitamin D, and colorectal cancer risk : The fukuoka colorectal cancer study. / Mizoue, Tetsuya; Kimura, Yasumi; Toyomura, Kengo; Nagano, Jun; Kono, Suminori; Mibu, Ryuichi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Yasunami, Yohichi; Maekawa, Takafumi; Takenaka, Kenji; Ichimiya, Hitoshi; Imaizumi, Nobutoshi.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 17, No. 10, 01.10.2008, p. 2800-2807.

Research output: Contribution to journalArticle

Mizoue, T, Kimura, Y, Toyomura, K, Nagano, J, Kono, S, Mibu, R, Tanaka, M, Kakeji, Y, Maehara, Y, Okamura, T, Ikejiri, K, Futami, K, Yasunami, Y, Maekawa, T, Takenaka, K, Ichimiya, H & Imaizumi, N 2008, 'Calcium, dairy foods, vitamin D, and colorectal cancer risk: The fukuoka colorectal cancer study', Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 10, pp. 2800-2807. https://doi.org/10.1158/1055-9965.EPI-08-0369
Mizoue, Tetsuya ; Kimura, Yasumi ; Toyomura, Kengo ; Nagano, Jun ; Kono, Suminori ; Mibu, Ryuichi ; Tanaka, Masao ; Kakeji, Yoshihiro ; Maehara, Yoshihiko ; Okamura, Takeshi ; Ikejiri, Koji ; Futami, Kitaroh ; Yasunami, Yohichi ; Maekawa, Takafumi ; Takenaka, Kenji ; Ichimiya, Hitoshi ; Imaizumi, Nobutoshi. / Calcium, dairy foods, vitamin D, and colorectal cancer risk : The fukuoka colorectal cancer study. In: Cancer Epidemiology Biomarkers and Prevention. 2008 ; Vol. 17, No. 10. pp. 2800-2807.
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