TY - JOUR
T1 - Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion
AU - Yamasaki, Shinya
AU - Kurita, Saori
AU - Ochiai, Asumi
AU - Hashimoto, Miya
AU - Sueki, Keisuke
AU - Utsunomiya, Satoshi
N1 - Funding Information:
This study was supported in part by the Ministry of Education, Culture, Sports, Science and Technology, Japan [15K18315 and 25820454 (S. Yamasaki)]. A part of this study (SEM analysis) was supported by the NIMS microstructural characterization platform as a program of the “Nanotechnology Platform” of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. We appreciate the Ultramicroscopy Research Center, Kyushu University, Japan, for the TEM measurements. The TEM measurements using uranyl acetate staining was conducted at Advanced Characterization Nanotechnology Platform of the University of Tokyo, supported by “Nanotechnology Platform” of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. We also thank the Chemical Analysis Division and the Open Facility, Research Facility Center for Science and Technology, University of Tsukuba, for the DLS measurements.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/11/15
Y1 - 2018/11/15
N2 - In order to achieve the highly efficient 99mTc production from 100MoO3 by the 100Mo(n, 2n)99Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.
AB - In order to achieve the highly efficient 99mTc production from 100MoO3 by the 100Mo(n, 2n)99Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.
UR - http://www.scopus.com/inward/record.url?scp=85049456019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049456019&partnerID=8YFLogxK
U2 - 10.1016/j.jcis.2018.07.007
DO - 10.1016/j.jcis.2018.07.007
M3 - Article
C2 - 29990783
AN - SCOPUS:85049456019
VL - 530
SP - 473
EP - 480
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
ER -