Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion

Shinya Yamasaki, Saori Kurita, Asumi Ochiai, Miya Hashimoto, Keisuke Sueki, Satoshi Utsunomiya

Research output: Contribution to journalArticle

Abstract

In order to achieve the highly efficient 99m Tc production from 100 MoO 3 by the 100 Mo(n, 2n) 99 Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO 4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO 4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO 4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.

Original languageEnglish
Pages (from-to)473-480
Number of pages8
JournalJournal of Colloid And Interface Science
Volume530
DOIs
Publication statusPublished - Nov 15 2018

Fingerprint

Liposomes
Phosphatidylcholines
Calcium
Fusion reactions
Nanoparticles
Transmission electron microscopy
molybdate
Choline
Nanocrystals
Suspensions
Drying
Membranes
Scanning electron microscopy
Ions

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Cite this

Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion. / Yamasaki, Shinya; Kurita, Saori; Ochiai, Asumi; Hashimoto, Miya; Sueki, Keisuke; Utsunomiya, Satoshi.

In: Journal of Colloid And Interface Science, Vol. 530, 15.11.2018, p. 473-480.

Research output: Contribution to journalArticle

Yamasaki, Shinya ; Kurita, Saori ; Ochiai, Asumi ; Hashimoto, Miya ; Sueki, Keisuke ; Utsunomiya, Satoshi. / Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion. In: Journal of Colloid And Interface Science. 2018 ; Vol. 530. pp. 473-480.
@article{88b6e18eef5e49c4a430e369d6cd9be6,
title = "Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion",
abstract = "In order to achieve the highly efficient 99m Tc production from 100 MoO 3 by the 100 Mo(n, 2n) 99 Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO 4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO 4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO 4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.",
author = "Shinya Yamasaki and Saori Kurita and Asumi Ochiai and Miya Hashimoto and Keisuke Sueki and Satoshi Utsunomiya",
year = "2018",
month = "11",
day = "15",
doi = "10.1016/j.jcis.2018.07.007",
language = "English",
volume = "530",
pages = "473--480",
journal = "Journal of Colloid and Interface Science",
issn = "0021-9797",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion

AU - Yamasaki, Shinya

AU - Kurita, Saori

AU - Ochiai, Asumi

AU - Hashimoto, Miya

AU - Sueki, Keisuke

AU - Utsunomiya, Satoshi

PY - 2018/11/15

Y1 - 2018/11/15

N2 - In order to achieve the highly efficient 99m Tc production from 100 MoO 3 by the 100 Mo(n, 2n) 99 Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO 4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO 4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO 4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.

AB - In order to achieve the highly efficient 99m Tc production from 100 MoO 3 by the 100 Mo(n, 2n) 99 Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO 4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO 4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO 4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.

UR - http://www.scopus.com/inward/record.url?scp=85049456019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049456019&partnerID=8YFLogxK

U2 - 10.1016/j.jcis.2018.07.007

DO - 10.1016/j.jcis.2018.07.007

M3 - Article

C2 - 29990783

AN - SCOPUS:85049456019

VL - 530

SP - 473

EP - 480

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

SN - 0021-9797

ER -