Abstract
In order to achieve the highly efficient 99m Tc production from 100 MoO 3 by the 100 Mo(n, 2n) 99 Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO 4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO 4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO 4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.
| Original language | English |
|---|---|
| Pages (from-to) | 473-480 |
| Number of pages | 8 |
| Journal | Journal of Colloid And Interface Science |
| Volume | 530 |
| DOIs | |
| Publication status | Published - Nov 15 2018 |
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All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Surfaces, Coatings and Films
- Colloid and Surface Chemistry
Cite this
Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion. / Yamasaki, Shinya; Kurita, Saori; Ochiai, Asumi; Hashimoto, Miya; Sueki, Keisuke; Utsunomiya, Satoshi.
In: Journal of Colloid And Interface Science, Vol. 530, 15.11.2018, p. 473-480.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion
AU - Yamasaki, Shinya
AU - Kurita, Saori
AU - Ochiai, Asumi
AU - Hashimoto, Miya
AU - Sueki, Keisuke
AU - Utsunomiya, Satoshi
PY - 2018/11/15
Y1 - 2018/11/15
N2 - In order to achieve the highly efficient 99m Tc production from 100 MoO 3 by the 100 Mo(n, 2n) 99 Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO 4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO 4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO 4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.
AB - In order to achieve the highly efficient 99m Tc production from 100 MoO 3 by the 100 Mo(n, 2n) 99 Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO 4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO 4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO 4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.
UR - http://www.scopus.com/inward/record.url?scp=85049456019&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049456019&partnerID=8YFLogxK
U2 - 10.1016/j.jcis.2018.07.007
DO - 10.1016/j.jcis.2018.07.007
M3 - Article
C2 - 29990783
AN - SCOPUS:85049456019
VL - 530
SP - 473
EP - 480
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
ER -