Abstract
Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca2+) concentration is increased promoting the activation of various signaling cascades. While elevated Ca2+ in the cytosol initially comes from the endoplasmic reticulum (ER), a continuous influx of extracellular Ca2+ is required to maintain the increased level of cytosolic Ca2+. Store-operated Ca2+ entry manages this process, which is regulated by an ER calcium sensor, stromal interaction molecule (STIM). STIM proteins sense changes in the levels of Ca2+ stored within the ER lumen and regulates the Ca2+-release activated Ca2+ channel in the plasma membrane. This review focuses on the signaling pathways leading to Ca2+ influx and the role of Ca2+ signals in B cell functions.
| Original language | English |
|---|---|
| Pages (from-to) | 339-343 |
| Number of pages | 5 |
| Journal | Molecular Immunology |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Dec 1 2014 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Immunology
- Molecular Biology
Cite this
Calcium signaling in B cells : Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2. / Baba, Yoshihiro; Matsumoto, Masanori; Kurosaki, Tomohiro.
In: Molecular Immunology, Vol. 62, No. 2, 01.12.2014, p. 339-343.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Calcium signaling in B cells
T2 - Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2
AU - Baba, Yoshihiro
AU - Matsumoto, Masanori
AU - Kurosaki, Tomohiro
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca2+) concentration is increased promoting the activation of various signaling cascades. While elevated Ca2+ in the cytosol initially comes from the endoplasmic reticulum (ER), a continuous influx of extracellular Ca2+ is required to maintain the increased level of cytosolic Ca2+. Store-operated Ca2+ entry manages this process, which is regulated by an ER calcium sensor, stromal interaction molecule (STIM). STIM proteins sense changes in the levels of Ca2+ stored within the ER lumen and regulates the Ca2+-release activated Ca2+ channel in the plasma membrane. This review focuses on the signaling pathways leading to Ca2+ influx and the role of Ca2+ signals in B cell functions.
AB - Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca2+) concentration is increased promoting the activation of various signaling cascades. While elevated Ca2+ in the cytosol initially comes from the endoplasmic reticulum (ER), a continuous influx of extracellular Ca2+ is required to maintain the increased level of cytosolic Ca2+. Store-operated Ca2+ entry manages this process, which is regulated by an ER calcium sensor, stromal interaction molecule (STIM). STIM proteins sense changes in the levels of Ca2+ stored within the ER lumen and regulates the Ca2+-release activated Ca2+ channel in the plasma membrane. This review focuses on the signaling pathways leading to Ca2+ influx and the role of Ca2+ signals in B cell functions.
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U2 - 10.1016/j.molimm.2013.10.006
DO - 10.1016/j.molimm.2013.10.006
M3 - Review article
VL - 62
SP - 339
EP - 343
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
IS - 2
ER -