TY - JOUR
T1 - Calcium signaling in B cells
T2 - Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2
AU - Baba, Yoshihiro
AU - Matsumoto, Masanori
AU - Kurosaki, Tomohiro
N1 - Funding Information:
This work was supported by Grants-in-Aid from the Japan Science and Technology Agency and Core Research for Evolutional Science and Technology (T.K.) and by the Ministry of Education, Culture, Sports, Science and Technology, Japan (Y.B. and T.K.). We sincerely apologize to the many scientists whose work was not cited in the references owing to space limitations.
Publisher Copyright:
© 2013 Elsevier Ltd.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca2+) concentration is increased promoting the activation of various signaling cascades. While elevated Ca2+ in the cytosol initially comes from the endoplasmic reticulum (ER), a continuous influx of extracellular Ca2+ is required to maintain the increased level of cytosolic Ca2+. Store-operated Ca2+ entry manages this process, which is regulated by an ER calcium sensor, stromal interaction molecule (STIM). STIM proteins sense changes in the levels of Ca2+ stored within the ER lumen and regulates the Ca2+-release activated Ca2+ channel in the plasma membrane. This review focuses on the signaling pathways leading to Ca2+ influx and the role of Ca2+ signals in B cell functions.
AB - Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca2+) concentration is increased promoting the activation of various signaling cascades. While elevated Ca2+ in the cytosol initially comes from the endoplasmic reticulum (ER), a continuous influx of extracellular Ca2+ is required to maintain the increased level of cytosolic Ca2+. Store-operated Ca2+ entry manages this process, which is regulated by an ER calcium sensor, stromal interaction molecule (STIM). STIM proteins sense changes in the levels of Ca2+ stored within the ER lumen and regulates the Ca2+-release activated Ca2+ channel in the plasma membrane. This review focuses on the signaling pathways leading to Ca2+ influx and the role of Ca2+ signals in B cell functions.
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U2 - 10.1016/j.molimm.2013.10.006
DO - 10.1016/j.molimm.2013.10.006
M3 - Review article
C2 - 24246800
AN - SCOPUS:84908138046
VL - 62
SP - 339
EP - 343
JO - Immunochemistry
JF - Immunochemistry
SN - 0161-5890
IS - 2
ER -