Calcium signaling in B cells: Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2

Yoshihiro Baba, Masanori Matsumoto, Tomohiro Kurosaki

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Calcium signals are crucial for diverse cellular functions including adhesion, differentiation, proliferation, effector functions and gene expression. After engagement of the B cell receptor, the intracellular calcium ion (Ca2+) concentration is increased promoting the activation of various signaling cascades. While elevated Ca2+ in the cytosol initially comes from the endoplasmic reticulum (ER), a continuous influx of extracellular Ca2+ is required to maintain the increased level of cytosolic Ca2+. Store-operated Ca2+ entry manages this process, which is regulated by an ER calcium sensor, stromal interaction molecule (STIM). STIM proteins sense changes in the levels of Ca2+ stored within the ER lumen and regulates the Ca2+-release activated Ca2+ channel in the plasma membrane. This review focuses on the signaling pathways leading to Ca2+ influx and the role of Ca2+ signals in B cell functions.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalMolecular Immunology
Issue number2
Publication statusPublished - Dec 1 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology

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