Calix[6]arene acetic acid extraction behavior and specificity with respect to nucleobases

Kojiro Shimojo, Tatsuya Oshima, Masahiro Goto

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    The extraction behavior of various nucleobases was investigated with a series of calixarene derivatives. A calix[6]arene acetic acid was found to extract around 80% of adenine from an aqueous phase, and showed the highest specificity for adenine among all the nucleobases tested. The important factors influencing the recognition properties of calixarene were discovered to be its cyclic structure, its cavity size, and the functional carboxylic acid groups. The carbonyl group and the position of the amino group in the guest molecules also affect the extraction efficiency. Calix[6]arene forms a stable 1:1 complex with adenine by entrapping it into the cavity. Adenine was readily recovered from the organic phase by contacting with a fresh acidic solution.

    Original languageEnglish
    Pages (from-to)163-171
    Number of pages9
    JournalAnalytica Chimica Acta
    Volume521
    Issue number2
    DOIs
    Publication statusPublished - Sep 13 2004

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry
    • Biochemistry
    • Environmental Chemistry
    • Spectroscopy

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