Calmodulin antagonists inhibit Ca2+ uptake of mitochondria of guinea pig peritoneal macrophages

Masato Hirata, Eiichi Suematsu, Toshitaka Koga

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The Ca2+ uptake of the mitochondria of guinea pig peritoneal macrophages was not stimulated by the addition of calmodulin. However, calmodulin antagonists, both phenotiazines and N-naphthalenesulfonamides, in low concentrations inhibited the Ca2+ uptake of the mitochondoria, as compared to the inhibition of the calmodulin-dependent stimulation of brain phosphodiesterase. These calmodulin antagonists appear to have severe side effects on active processes of the mitochondria and which are unrelated to the specific effect on calmodulin.

Original languageEnglish
Pages (from-to)1176-1181
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume105
Issue number3
DOIs
Publication statusPublished - Apr 14 1982

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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