Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats

Takuya Kishi, Yoshitaka Hirooka, Kiyohiro Ogawa, Satomi Konno, Kenji Sunagawa

Research output: Contribution to journalArticle

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Abstract

In the patients and animals with metabolic syndrome (MetS), sympathetic nerve activity (SNA) is increased. We have demonstrated that oxidative stress in the rostral ventrolateral medulla (RVLM), a vasomotor center in the brainstem, increases SNA. The aim of the present study was to determine whether calorie restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced obesity rats. Male Sprague-Dawley rats were fed on a high-fat diet and segregated into obesity-prone (OP) showing a MetS profile and obesity-resistant (OR) after 13 weeks. Obesity-prone was divided into OP treated with calorie restriction (CR-OP) for 8 weeks and control (CTR-OP). Systolic blood pressure (SBP), heart rate (HR), SNA, and thiobarbituric acid-reactive substances (TBARS) levels as a marker of oxidative stress in the RVLM were significantly higher and the depressor effects due to the microinjection of tempol, a superoxide dismutase mimetic into the RVLM, were significantly greater in OP than in OR. Body weight was significantly lower in CR-OP than in CTR-OP. SBP, HR, SNA, TBARS, and the depressor effects due to the microinjection of tempol into the RVLM were significantly lower in CR-OP than in CTR-OP. These results suggest that calorie restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced obesity rats.

Original languageEnglish
Pages (from-to)240-245
Number of pages6
JournalClinical and Experimental Hypertension
Volume33
Issue number4
DOIs
Publication statusPublished - Jul 1 2011

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Obesity
Antioxidants
Blood Pressure
Thiobarbituric Acid Reactive Substances
Microinjections
Oxidative Stress
Heart Rate
Metabolome
High Fat Diet
Brain Stem
Superoxide Dismutase
Sprague Dawley Rats
Body Weight

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

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Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats. / Kishi, Takuya; Hirooka, Yoshitaka; Ogawa, Kiyohiro; Konno, Satomi; Sunagawa, Kenji.

In: Clinical and Experimental Hypertension, Vol. 33, No. 4, 01.07.2011, p. 240-245.

Research output: Contribution to journalArticle

Kishi, Takuya ; Hirooka, Yoshitaka ; Ogawa, Kiyohiro ; Konno, Satomi ; Sunagawa, Kenji. / Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats. In: Clinical and Experimental Hypertension. 2011 ; Vol. 33, No. 4. pp. 240-245.
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