Calories versus protein in onset of renal disease in NZB x NZW mice

B. C. Johnson, A. Gajjar, C. Kubo, R. A. Good

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Autoimmunity-prone (NZB x NZW)F1 (B/W) female mice are used as a model of human lupus erythematosus. When full-fed, these mice die of glomerulonephritis between 7 and 11 (average 9) months of age. When food intake is restricted to 60% of calories, the onset of this disease is delayed and the mice live greatly prolonged lives free of disease. Since high protein intake is commonly associated with acceleration of kidney damage in humans and experimental animals, the current experiments were designed to employ diets in which protein concentration was as high as possible. The observations demonstrate clearly that with this model of autoimmune disease total calorie intake (from whatever source) exerts an overriding influence on life span. A higher calorie intake leads to early death and restricted-calorie intake leads to an increased life span. When B/W mice are full-fed, with respect to calories, feeding diets of greatly differing protein composition did not influence life span significantly. By contrast, calorie restriction of diets, even of very high protein content or of lower protein content, greatly prolonged life of B/W mice. Even with exceedingly high protein intake (>83% of the calories) it is not protein per se but the total calorie intake that exerts the greatest influence that determines length of life in mice of this autoimmunity- and glomerulonephritis-prone strain.

Original languageEnglish
Pages (from-to)5659-5662
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number15
DOIs
Publication statusPublished - Jan 1 1986
Externally publishedYes

Fingerprint

Kidney
Proteins
Glomerulonephritis
Diet
Autoimmunity
Autoimmune Diseases
Eating

All Science Journal Classification (ASJC) codes

  • General

Cite this

Calories versus protein in onset of renal disease in NZB x NZW mice. / Johnson, B. C.; Gajjar, A.; Kubo, C.; Good, R. A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 15, 01.01.1986, p. 5659-5662.

Research output: Contribution to journalArticle

@article{7569f368fe4741b3a013cae2baebaf0d,
title = "Calories versus protein in onset of renal disease in NZB x NZW mice",
abstract = "Autoimmunity-prone (NZB x NZW)F1 (B/W) female mice are used as a model of human lupus erythematosus. When full-fed, these mice die of glomerulonephritis between 7 and 11 (average 9) months of age. When food intake is restricted to 60{\%} of calories, the onset of this disease is delayed and the mice live greatly prolonged lives free of disease. Since high protein intake is commonly associated with acceleration of kidney damage in humans and experimental animals, the current experiments were designed to employ diets in which protein concentration was as high as possible. The observations demonstrate clearly that with this model of autoimmune disease total calorie intake (from whatever source) exerts an overriding influence on life span. A higher calorie intake leads to early death and restricted-calorie intake leads to an increased life span. When B/W mice are full-fed, with respect to calories, feeding diets of greatly differing protein composition did not influence life span significantly. By contrast, calorie restriction of diets, even of very high protein content or of lower protein content, greatly prolonged life of B/W mice. Even with exceedingly high protein intake (>83{\%} of the calories) it is not protein per se but the total calorie intake that exerts the greatest influence that determines length of life in mice of this autoimmunity- and glomerulonephritis-prone strain.",
author = "Johnson, {B. C.} and A. Gajjar and C. Kubo and Good, {R. A.}",
year = "1986",
month = "1",
day = "1",
doi = "10.1073/pnas.83.15.5659",
language = "English",
volume = "83",
pages = "5659--5662",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "15",

}

TY - JOUR

T1 - Calories versus protein in onset of renal disease in NZB x NZW mice

AU - Johnson, B. C.

AU - Gajjar, A.

AU - Kubo, C.

AU - Good, R. A.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Autoimmunity-prone (NZB x NZW)F1 (B/W) female mice are used as a model of human lupus erythematosus. When full-fed, these mice die of glomerulonephritis between 7 and 11 (average 9) months of age. When food intake is restricted to 60% of calories, the onset of this disease is delayed and the mice live greatly prolonged lives free of disease. Since high protein intake is commonly associated with acceleration of kidney damage in humans and experimental animals, the current experiments were designed to employ diets in which protein concentration was as high as possible. The observations demonstrate clearly that with this model of autoimmune disease total calorie intake (from whatever source) exerts an overriding influence on life span. A higher calorie intake leads to early death and restricted-calorie intake leads to an increased life span. When B/W mice are full-fed, with respect to calories, feeding diets of greatly differing protein composition did not influence life span significantly. By contrast, calorie restriction of diets, even of very high protein content or of lower protein content, greatly prolonged life of B/W mice. Even with exceedingly high protein intake (>83% of the calories) it is not protein per se but the total calorie intake that exerts the greatest influence that determines length of life in mice of this autoimmunity- and glomerulonephritis-prone strain.

AB - Autoimmunity-prone (NZB x NZW)F1 (B/W) female mice are used as a model of human lupus erythematosus. When full-fed, these mice die of glomerulonephritis between 7 and 11 (average 9) months of age. When food intake is restricted to 60% of calories, the onset of this disease is delayed and the mice live greatly prolonged lives free of disease. Since high protein intake is commonly associated with acceleration of kidney damage in humans and experimental animals, the current experiments were designed to employ diets in which protein concentration was as high as possible. The observations demonstrate clearly that with this model of autoimmune disease total calorie intake (from whatever source) exerts an overriding influence on life span. A higher calorie intake leads to early death and restricted-calorie intake leads to an increased life span. When B/W mice are full-fed, with respect to calories, feeding diets of greatly differing protein composition did not influence life span significantly. By contrast, calorie restriction of diets, even of very high protein content or of lower protein content, greatly prolonged life of B/W mice. Even with exceedingly high protein intake (>83% of the calories) it is not protein per se but the total calorie intake that exerts the greatest influence that determines length of life in mice of this autoimmunity- and glomerulonephritis-prone strain.

UR - http://www.scopus.com/inward/record.url?scp=0022524518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022524518&partnerID=8YFLogxK

U2 - 10.1073/pnas.83.15.5659

DO - 10.1073/pnas.83.15.5659

M3 - Article

C2 - 3461453

AN - SCOPUS:0022524518

VL - 83

SP - 5659

EP - 5662

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 15

ER -