Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Nobutoshi Kawamura, Hua Piao, Motozumi Minohara, Takuya Matsushita, Susumu Kusunoki, Hiroshi Matsumoto, Kazuhiro Ikenaka, Yoshimitsu Mizunoe, Jun ichi Kira

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalJournal of Neuroimmunology
Volume240-241
DOIs
Publication statusPublished - Dec 15 2011

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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