Cancer cell death induced by the intracellular self-assembly of an enzyme-responsive supramolecular gelator

Akiko Tanaka, Yuki Fukuoka, Yuka Morimoto, Takafumi Honjo, Daisuke Koda, Masahiro Goto, Tatsuo Maruyama

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

We report cancer cell death initiated by the intracellular molecular self-assembly of a peptide lipid, which was derived from a gelator precursor. The gelator precursor was designed to form nanofibers via molecular self-assembly, after cleavage by a cancer-related enzyme (matrix metalloproteinase-7, MMP-7), leading to hydrogelation. The gelator precursor exhibited remarkable cytotoxicity to five different cancer cell lines, while the precursor exhibited low cytotoxicity to normal cells. Cancer cells secrete excessive amounts of MMP-7, which converted the precursor into a supramolecular gelator prior to its uptake by the cells. Once inside the cells, the supramolecular gelator formed a gel via molecular self-assembly, exerting vital stress on the cancer cells. The present study thus describes a new drug where molecular self-assembly acts as the mechanism of cytotoxicity.

Original languageEnglish
Pages (from-to)770-775
Number of pages6
JournalJournal of the American Chemical Society
Volume137
Issue number2
DOIs
Publication statusPublished - Jan 21 2015

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this