Cancer immunotherapy using NKG2D and DNAM-1 systems

Takashi Morisaki, Hideya Onishi, Mitsuo Katano

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)


Although tumor antigen-specific immunotherapy, such as dendritic cell vaccine, has recently emerged as a promising clinical approach, one limitation of tumor antigen- and T-cell receptor (TcR)- specific immunotherapy is antigen-specific inhibition by antigen-specific regulatory T-cell and myeloid suppressor cells. Therefore, immunotherapy using a TcR-independent mechanism may be an alternative immunotherapeutic strategy. NKG2D (natural killer, group 2, member D) and DNAX accessory molecule-1 (DNAM-1) are both activated receptors that are strongly expressed on T-cells, γδT-cells, and NK cells. Therefore, the expression of ligands for NKG2D and DNAM-1 on tumor cells plays an important role in tumor opsonization by immune effector cell targeting. Various modulatory methods for up-regulating NKG2D and DNAM-1-ligands have been reported, and included chemotherapeutic agents and hyperthermia. Although there are many obstacles to the utilization of NKG2D and DNAM-1 for cancer therapy, combined treatments using immune cell therapy and chemotherapy that take advantage of NKG2D and DNAM-1 may be an ideal approach.

Original languageEnglish
Pages (from-to)2241-2247
Number of pages7
JournalAnticancer research
Issue number6
Publication statusPublished - Jun 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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