Cancer-specific DDS using stimuli-responsive polymers

Research output: Contribution to journalArticle

Abstract

Cancer chemotherapy has a serious difficulty with its poor cell specificity. DDS using nano-medicine consisting of polymer materials will be one of the most promising strategies to address this issue. Almost all cancer nano-medicines uses enhanced permeability and retention effect (EPR effect) based on extravasation of huge molecules in tumor neovasculature. As an additional effect, cancer specific ligand-receptor interaction is also available to enhance the binding ability of nano-medicine to cancer cells. Although these strategies realize significant drug accumulation in tumors compared with small drug administration, greater amount of nanomedicine may still be distributed to other non-target organs. In this context, Stimuli-responsive polymers have been applied to enhance the contrast of drug concentration between tumor and normal cells. In this review, recent progress of cancer DDS materials using a stimuli-responsive strategy is reviewed. Future directions for ideal cancer nanomedicine is also considered.

Original languageEnglish
Pages (from-to)452-456
Number of pages5
JournalKobunshi
Volume62
Issue number8
Publication statusPublished - Aug 2013

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All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

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