Cancer stem cells depend on their own niche

Yoshihiro Kano; Hideshi Ishii; Masamitsu Konno; Katsuya Ohta; Shimpei Nishikawa; Takahito Fukusumi; Atsushi Hamabe; Shinichiro Hasegawa; Hisataka Ogawa; Miyuki Ozaki; Yuko Noguchi; Daisuke Sakai; Naotsugu Haraguchi; Toshihiro Kudo; Taroh Satoh; Yuichiro Doki; Masaki Mori

Cancer stem cells depend on their own niche

Yoshihiro Kano, Hideshi Ishii, Masamitsu Konno, Katsuya Ohta, Shimpei Nishikawa, Takahito Fukusumi, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Miyuki Ozaki, Yuko Noguchi, Daisuke Sakai, Naotsugu Haraguchi, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori

Research output: Contribution to journal › Review article › peer-review

Abstract

It is considered that cancer stem cells have the same characteristics as normal stem cells, such as drug-resistance, self--renewal, differentiation, and tissue-formation. Normal stem cells depend on their surroundings, a niche. Cancer stem cells may also depend on their own niche. Because cancer stem cells are resistant to present remedies, it is important to find a remedy targeting cancer stem cells. The remedy must not only target cancer stem cells themselves but also target the niche surrounding the cancer stem cells.

Original language	English
Pages (from-to)	419-423
Number of pages	5
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	40
Issue number	4
Publication status	Published - Apr 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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Cancer stem cells depend on their own niche. / Kano, Yoshihiro; Ishii, Hideshi; Konno, Masamitsu; Ohta, Katsuya; Nishikawa, Shimpei; Fukusumi, Takahito; Hamabe, Atsushi; Hasegawa, Shinichiro; Ogawa, Hisataka; Ozaki, Miyuki; Noguchi, Yuko; Sakai, Daisuke; Haraguchi, Naotsugu; Kudo, Toshihiro; Satoh, Taroh; Doki, Yuichiro; Mori, Masaki.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 40, No. 4, 04.2013, p. 419-423.

Research output: Contribution to journal › Review article › peer-review

Kano, Yoshihiro ; Ishii, Hideshi ; Konno, Masamitsu ; Ohta, Katsuya ; Nishikawa, Shimpei ; Fukusumi, Takahito ; Hamabe, Atsushi ; Hasegawa, Shinichiro ; Ogawa, Hisataka ; Ozaki, Miyuki ; Noguchi, Yuko ; Sakai, Daisuke ; Haraguchi, Naotsugu ; Kudo, Toshihiro ; Satoh, Taroh ; Doki, Yuichiro ; Mori, Masaki. / Cancer stem cells depend on their own niche. In: Japanese Journal of Cancer and Chemotherapy. 2013 ; Vol. 40, No. 4. pp. 419-423.

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abstract = "It is considered that cancer stem cells have the same characteristics as normal stem cells, such as drug-resistance, self--renewal, differentiation, and tissue-formation. Normal stem cells depend on their surroundings, a niche. Cancer stem cells may also depend on their own niche. Because cancer stem cells are resistant to present remedies, it is important to find a remedy targeting cancer stem cells. The remedy must not only target cancer stem cells themselves but also target the niche surrounding the cancer stem cells.",

author = "Yoshihiro Kano and Hideshi Ishii and Masamitsu Konno and Katsuya Ohta and Shimpei Nishikawa and Takahito Fukusumi and Atsushi Hamabe and Shinichiro Hasegawa and Hisataka Ogawa and Miyuki Ozaki and Yuko Noguchi and Daisuke Sakai and Naotsugu Haraguchi and Toshihiro Kudo and Taroh Satoh and Yuichiro Doki and Masaki Mori",

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AU - Kano, Yoshihiro

AU - Ishii, Hideshi

AU - Konno, Masamitsu

AU - Ohta, Katsuya

AU - Nishikawa, Shimpei

AU - Fukusumi, Takahito

AU - Hamabe, Atsushi

AU - Hasegawa, Shinichiro

AU - Ogawa, Hisataka

AU - Ozaki, Miyuki

AU - Noguchi, Yuko

AU - Sakai, Daisuke

AU - Haraguchi, Naotsugu

AU - Kudo, Toshihiro

AU - Satoh, Taroh

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2013/4

Y1 - 2013/4

N2 - It is considered that cancer stem cells have the same characteristics as normal stem cells, such as drug-resistance, self--renewal, differentiation, and tissue-formation. Normal stem cells depend on their surroundings, a niche. Cancer stem cells may also depend on their own niche. Because cancer stem cells are resistant to present remedies, it is important to find a remedy targeting cancer stem cells. The remedy must not only target cancer stem cells themselves but also target the niche surrounding the cancer stem cells.

AB - It is considered that cancer stem cells have the same characteristics as normal stem cells, such as drug-resistance, self--renewal, differentiation, and tissue-formation. Normal stem cells depend on their surroundings, a niche. Cancer stem cells may also depend on their own niche. Because cancer stem cells are resistant to present remedies, it is important to find a remedy targeting cancer stem cells. The remedy must not only target cancer stem cells themselves but also target the niche surrounding the cancer stem cells.

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M3 - Review article

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JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

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Cancer stem cells depend on their own niche

Abstract

All Science Journal Classification (ASJC) codes

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