Cancer stem cells of the digestive system

Hugh S. Colvin, Naohiro Nishida, Jun Koseki, Masamitsu Konno, Koichi Kawamoto, Kenta Tsunekuni, Yuichiro Doki, Masaki Mori, Hideshi Ishii

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2 Citations (Scopus)

Abstract

Stem cells of the digestive system are ideal in many ways for research, given they are abundant, highly proliferative and have a uniform structural arrangement. This in turn has enormously aided the research of cancer stem cells of the digestive system, which is now shaping our understanding of cancer stem cells. In this review, the recent advances in the understanding of cancer stem cells of the digestive system have been summarized, including aspects such as their identification, origin, cell-cycle dormancy, relationship with epithelial-mesenchymal transition, cellular metabolism and the underlying molecular mechanisms. Newly acquired knowledge concerning cancer stem cells have led to the development of novel cancer therapeutics with provisional yet encouraging results.

Original languageEnglish
Pages (from-to)1141-1149
Number of pages9
JournalJapanese journal of clinical oncology
Volume44
Issue number12
DOIs
Publication statusPublished - Dec 1 2014
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Colvin, H. S., Nishida, N., Koseki, J., Konno, M., Kawamoto, K., Tsunekuni, K., ... Ishii, H. (2014). Cancer stem cells of the digestive system. Japanese journal of clinical oncology, 44(12), 1141-1149. https://doi.org/10.1093/jjco/hyu146