Abstract
The principle concept of cancer stem cells (CSCs) giving rise to the carcinogenesis, relapse or metastasis of malignancy is broadly recognized. On the other hand, circulating tumor cells (CTCs) also plays important roles in relapse or metastasis of malignancy, and there has been much focused on the association between CSCs and CTCs in cancer cases. The technical innovations for detection of CTCs enabled us to unveil the nature of CTCs. We now realize that CTCs isolated by cell surface antibodies, such as DCLK1, LGR5 indicated CSC properties, and CTCs with epitherial-mesenchymal transition(EMT) phenotype showed characteristics of CSCs.
| Original language | English |
|---|---|
| Pages (from-to) | 806-810 |
| Number of pages | 5 |
| Journal | Nihon rinsho. Japanese journal of clinical medicine |
| Volume | 73 |
| Issue number | 5 |
| Publication status | Published - May 1 2015 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Cancer stemness and circulating tumor cells. / Saito, Tomoko; Mimori, Koshi.
In: Nihon rinsho. Japanese journal of clinical medicine, Vol. 73, No. 5, 01.05.2015, p. 806-810.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cancer stemness and circulating tumor cells
AU - Saito, Tomoko
AU - Mimori, Koshi
PY - 2015/5/1
Y1 - 2015/5/1
N2 - The principle concept of cancer stem cells (CSCs) giving rise to the carcinogenesis, relapse or metastasis of malignancy is broadly recognized. On the other hand, circulating tumor cells (CTCs) also plays important roles in relapse or metastasis of malignancy, and there has been much focused on the association between CSCs and CTCs in cancer cases. The technical innovations for detection of CTCs enabled us to unveil the nature of CTCs. We now realize that CTCs isolated by cell surface antibodies, such as DCLK1, LGR5 indicated CSC properties, and CTCs with epitherial-mesenchymal transition(EMT) phenotype showed characteristics of CSCs.
AB - The principle concept of cancer stem cells (CSCs) giving rise to the carcinogenesis, relapse or metastasis of malignancy is broadly recognized. On the other hand, circulating tumor cells (CTCs) also plays important roles in relapse or metastasis of malignancy, and there has been much focused on the association between CSCs and CTCs in cancer cases. The technical innovations for detection of CTCs enabled us to unveil the nature of CTCs. We now realize that CTCs isolated by cell surface antibodies, such as DCLK1, LGR5 indicated CSC properties, and CTCs with epitherial-mesenchymal transition(EMT) phenotype showed characteristics of CSCs.
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M3 - Article
C2 - 25985635
AN - SCOPUS:84938693075
VL - 73
SP - 806
EP - 810
JO - Astrophysical Journal
JF - Astrophysical Journal
SN - 0004-637X
IS - 5
ER -