TY - JOUR
T1 - Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism
AU - Hayakawa, Kazuhide
AU - Mishima, Kenichi
AU - Abe, Kohji
AU - Hasebe, Nobuyoshi
AU - Takamatsu, Fumie
AU - Yasuda, Hiromi
AU - Ikeda, Tomoaki
AU - Inui, Keiichiro
AU - Egashira, Nobuaki
AU - Iwasaki, Katsunori
AU - Fujiwara, Michihiro
PY - 2004/10/25
Y1 - 2004/10/25
N2 - Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Δ 9-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Δ 9-tetrahydrocannabinol but not cannabidiol were inhibited by SRI41716, a cannabinoid CBI receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Δ 9-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SRI41716. These results surely show that the neuroprotective effect of Δ 9- tetrahydrocannabinol are via a CBI receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CBI blockade and of hypothermia.
AB - Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Δ 9-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Δ 9-tetrahydrocannabinol but not cannabidiol were inhibited by SRI41716, a cannabinoid CBI receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Δ 9-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SRI41716. These results surely show that the neuroprotective effect of Δ 9- tetrahydrocannabinol are via a CBI receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CBI blockade and of hypothermia.
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U2 - 10.1097/00001756-200410250-00016
DO - 10.1097/00001756-200410250-00016
M3 - Article
C2 - 15640760
AN - SCOPUS:8444238592
SN - 0959-4965
VL - 15
SP - 2381
EP - 2385
JO - NeuroReport
JF - NeuroReport
IS - 15
ER -