Cannabis, 21. Biotransformation of cannabinol to its glycosides by in vitro plant tissue

Hiroyuki Tanaka, Satoshi Morimoto, Yukihiro Shoyama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A marijuana compound, cannabinol [1], was converted to two metabolites using in vitro tissue of Pinellia ternata. The structures of the metabolites were determined to be cannabinol-O-β-d-glucopyranoside [2] and 9′-hydroxycannabinol-O-β-d-glucopyranoside [3] by 1H nmr and 13C nmr. From the time course experiments, 1 was absorbed rapidly in the tissues and glycosylated. Hydroxylation at the pentyl group occurred, and its metabolite was secreted in the medium.

Original languageEnglish
Pages (from-to)2068-2072
Number of pages5
JournalJournal of Natural Products
Volume56
Issue number12
DOIs
Publication statusPublished - Dec 1993

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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