Cannabis, 21. Biotransformation of cannabinol to its glycosides by in vitro plant tissue

Hiroyuki Tanaka, Satoshi Morimoto, Yukihiro Shoyama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A marijuana compound, cannabinol [1], was converted to two metabolites using in vitro tissue of Pinellia ternata. The structures of the metabolites were determined to be cannabinol-O-β-d-glucopyranoside [2] and 9′-hydroxycannabinol-O-β-d-glucopyranoside [3] by 1H nmr and 13C nmr. From the time course experiments, 1 was absorbed rapidly in the tissues and glycosylated. Hydroxylation at the pentyl group occurred, and its metabolite was secreted in the medium.

Original languageEnglish
Pages (from-to)2068-2072
Number of pages5
JournalJournal of Natural Products
Volume56
Issue number12
DOIs
Publication statusPublished - Jan 1 1993

Fingerprint

Cannabinol
Cannabis
Glycosides
Biotransformation
Metabolites
Pinellia
Tissue
Hydroxylation
In Vitro Techniques
Experiments

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Cannabis, 21. Biotransformation of cannabinol to its glycosides by in vitro plant tissue. / Tanaka, Hiroyuki; Morimoto, Satoshi; Shoyama, Yukihiro.

In: Journal of Natural Products, Vol. 56, No. 12, 01.01.1993, p. 2068-2072.

Research output: Contribution to journalArticle

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