Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia

Seon Cheol Park, Hong Seok Oh, Adarsh Tripathi, Roy Abraham Kallivayalil, Ajit Avasthi, Sandeep Grover, Andi Jayalangkara Tanra, Shigenobu Kanba, Takahiro Kato, Toshiya Inada, Kok Yoon Chee, Mian Yoon Chong, Shih Ku Lin, Kang Sim, Yu Tao Xiang, Chay Hoon Tan, Afzal Javed, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park

Research output: Contribution to journalArticle

Abstract

Background: Although cannabis use has been linked with schizophrenia in a dose–response pattern, to our knowledge, the relationship between cannabis and schizophrenia has rarely been reported in Asian population. Aim: We compared the clinical characteristics and psychotropic prescription patterns between cannabis users and non-users among Asian patients with schizophrenia. Moreover, we aimed to identify the independent correlates of cannabis use in these subjects. Methods: We performed the analysis of the data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), a collaborative consortium survey used to collate the prescription patterns for antipsychotic and other psychotropic medications in patients with schizophrenia in Asia. We included 132 schizophrenia patients in the group of lifetime cannabis use and 1756 in the group that had never used cannabis. A binary logistic model was fitted to detect the clinical correlates of lifetime cannabis use. Results: Adjusting for the effects of age, sex, geographical region, income group, duration of untreated psychosis, and Charlson comordity index level, a binary logistic regression model revealed that lifetime cannabis use was independently associated with aggressive behavior [adjusted odds ratio (aOR) = 1.582, 95% confidence interval (CI) = 1.006–2.490, p =.047] and with long-acting injectable antipsychotic treatment (aOR = 1.796, 95% CI = 1.444–2.820, p =.001). Conclusion: Our findings indicate a close link between lifetime cannabis use and aggressive behavior. The use of long-acting, injectable antipsychotics preferentially treats the aggressive behavior cannabis users among patients with schizophrenia in Asia, especially, the South or Southeast Asia.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalNordic Journal of Psychiatry
Volume73
Issue number6
DOIs
Publication statusPublished - Aug 18 2019

Fingerprint

Cannabis
Antipsychotic Agents
Schizophrenia
Injections
Prescriptions
Therapeutics
Logistic Models
Odds Ratio
Confidence Intervals
Southeastern Asia
Psychotic Disorders

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia. / Park, Seon Cheol; Oh, Hong Seok; Tripathi, Adarsh; Kallivayalil, Roy Abraham; Avasthi, Ajit; Grover, Sandeep; Tanra, Andi Jayalangkara; Kanba, Shigenobu; Kato, Takahiro; Inada, Toshiya; Chee, Kok Yoon; Chong, Mian Yoon; Lin, Shih Ku; Sim, Kang; Xiang, Yu Tao; Tan, Chay Hoon; Javed, Afzal; Sartorius, Norman; Shinfuku, Naotaka; Park, Yong Chon.

In: Nordic Journal of Psychiatry, Vol. 73, No. 6, 18.08.2019, p. 323-330.

Research output: Contribution to journalArticle

Park, SC, Oh, HS, Tripathi, A, Kallivayalil, RA, Avasthi, A, Grover, S, Tanra, AJ, Kanba, S, Kato, T, Inada, T, Chee, KY, Chong, MY, Lin, SK, Sim, K, Xiang, YT, Tan, CH, Javed, A, Sartorius, N, Shinfuku, N & Park, YC 2019, 'Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia', Nordic Journal of Psychiatry, vol. 73, no. 6, pp. 323-330. https://doi.org/10.1080/08039488.2019.1632381
Park, Seon Cheol ; Oh, Hong Seok ; Tripathi, Adarsh ; Kallivayalil, Roy Abraham ; Avasthi, Ajit ; Grover, Sandeep ; Tanra, Andi Jayalangkara ; Kanba, Shigenobu ; Kato, Takahiro ; Inada, Toshiya ; Chee, Kok Yoon ; Chong, Mian Yoon ; Lin, Shih Ku ; Sim, Kang ; Xiang, Yu Tao ; Tan, Chay Hoon ; Javed, Afzal ; Sartorius, Norman ; Shinfuku, Naotaka ; Park, Yong Chon. / Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia. In: Nordic Journal of Psychiatry. 2019 ; Vol. 73, No. 6. pp. 323-330.
@article{a698583ab2f44a58ba36e18390f1aba6,
title = "Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia",
abstract = "Background: Although cannabis use has been linked with schizophrenia in a dose–response pattern, to our knowledge, the relationship between cannabis and schizophrenia has rarely been reported in Asian population. Aim: We compared the clinical characteristics and psychotropic prescription patterns between cannabis users and non-users among Asian patients with schizophrenia. Moreover, we aimed to identify the independent correlates of cannabis use in these subjects. Methods: We performed the analysis of the data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), a collaborative consortium survey used to collate the prescription patterns for antipsychotic and other psychotropic medications in patients with schizophrenia in Asia. We included 132 schizophrenia patients in the group of lifetime cannabis use and 1756 in the group that had never used cannabis. A binary logistic model was fitted to detect the clinical correlates of lifetime cannabis use. Results: Adjusting for the effects of age, sex, geographical region, income group, duration of untreated psychosis, and Charlson comordity index level, a binary logistic regression model revealed that lifetime cannabis use was independently associated with aggressive behavior [adjusted odds ratio (aOR) = 1.582, 95{\%} confidence interval (CI) = 1.006–2.490, p =.047] and with long-acting injectable antipsychotic treatment (aOR = 1.796, 95{\%} CI = 1.444–2.820, p =.001). Conclusion: Our findings indicate a close link between lifetime cannabis use and aggressive behavior. The use of long-acting, injectable antipsychotics preferentially treats the aggressive behavior cannabis users among patients with schizophrenia in Asia, especially, the South or Southeast Asia.",
author = "Park, {Seon Cheol} and Oh, {Hong Seok} and Adarsh Tripathi and Kallivayalil, {Roy Abraham} and Ajit Avasthi and Sandeep Grover and Tanra, {Andi Jayalangkara} and Shigenobu Kanba and Takahiro Kato and Toshiya Inada and Chee, {Kok Yoon} and Chong, {Mian Yoon} and Lin, {Shih Ku} and Kang Sim and Xiang, {Yu Tao} and Tan, {Chay Hoon} and Afzal Javed and Norman Sartorius and Naotaka Shinfuku and Park, {Yong Chon}",
year = "2019",
month = "8",
day = "18",
doi = "10.1080/08039488.2019.1632381",
language = "English",
volume = "73",
pages = "323--330",
journal = "Nordic Journal of Psychiatry",
issn = "0803-9488",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia

AU - Park, Seon Cheol

AU - Oh, Hong Seok

AU - Tripathi, Adarsh

AU - Kallivayalil, Roy Abraham

AU - Avasthi, Ajit

AU - Grover, Sandeep

AU - Tanra, Andi Jayalangkara

AU - Kanba, Shigenobu

AU - Kato, Takahiro

AU - Inada, Toshiya

AU - Chee, Kok Yoon

AU - Chong, Mian Yoon

AU - Lin, Shih Ku

AU - Sim, Kang

AU - Xiang, Yu Tao

AU - Tan, Chay Hoon

AU - Javed, Afzal

AU - Sartorius, Norman

AU - Shinfuku, Naotaka

AU - Park, Yong Chon

PY - 2019/8/18

Y1 - 2019/8/18

N2 - Background: Although cannabis use has been linked with schizophrenia in a dose–response pattern, to our knowledge, the relationship between cannabis and schizophrenia has rarely been reported in Asian population. Aim: We compared the clinical characteristics and psychotropic prescription patterns between cannabis users and non-users among Asian patients with schizophrenia. Moreover, we aimed to identify the independent correlates of cannabis use in these subjects. Methods: We performed the analysis of the data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), a collaborative consortium survey used to collate the prescription patterns for antipsychotic and other psychotropic medications in patients with schizophrenia in Asia. We included 132 schizophrenia patients in the group of lifetime cannabis use and 1756 in the group that had never used cannabis. A binary logistic model was fitted to detect the clinical correlates of lifetime cannabis use. Results: Adjusting for the effects of age, sex, geographical region, income group, duration of untreated psychosis, and Charlson comordity index level, a binary logistic regression model revealed that lifetime cannabis use was independently associated with aggressive behavior [adjusted odds ratio (aOR) = 1.582, 95% confidence interval (CI) = 1.006–2.490, p =.047] and with long-acting injectable antipsychotic treatment (aOR = 1.796, 95% CI = 1.444–2.820, p =.001). Conclusion: Our findings indicate a close link between lifetime cannabis use and aggressive behavior. The use of long-acting, injectable antipsychotics preferentially treats the aggressive behavior cannabis users among patients with schizophrenia in Asia, especially, the South or Southeast Asia.

AB - Background: Although cannabis use has been linked with schizophrenia in a dose–response pattern, to our knowledge, the relationship between cannabis and schizophrenia has rarely been reported in Asian population. Aim: We compared the clinical characteristics and psychotropic prescription patterns between cannabis users and non-users among Asian patients with schizophrenia. Moreover, we aimed to identify the independent correlates of cannabis use in these subjects. Methods: We performed the analysis of the data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), a collaborative consortium survey used to collate the prescription patterns for antipsychotic and other psychotropic medications in patients with schizophrenia in Asia. We included 132 schizophrenia patients in the group of lifetime cannabis use and 1756 in the group that had never used cannabis. A binary logistic model was fitted to detect the clinical correlates of lifetime cannabis use. Results: Adjusting for the effects of age, sex, geographical region, income group, duration of untreated psychosis, and Charlson comordity index level, a binary logistic regression model revealed that lifetime cannabis use was independently associated with aggressive behavior [adjusted odds ratio (aOR) = 1.582, 95% confidence interval (CI) = 1.006–2.490, p =.047] and with long-acting injectable antipsychotic treatment (aOR = 1.796, 95% CI = 1.444–2.820, p =.001). Conclusion: Our findings indicate a close link between lifetime cannabis use and aggressive behavior. The use of long-acting, injectable antipsychotics preferentially treats the aggressive behavior cannabis users among patients with schizophrenia in Asia, especially, the South or Southeast Asia.

UR - http://www.scopus.com/inward/record.url?scp=85068355797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068355797&partnerID=8YFLogxK

U2 - 10.1080/08039488.2019.1632381

DO - 10.1080/08039488.2019.1632381

M3 - Article

VL - 73

SP - 323

EP - 330

JO - Nordic Journal of Psychiatry

JF - Nordic Journal of Psychiatry

SN - 0803-9488

IS - 6

ER -