Cannabis. XV. preparation and stability of Δ9-tetrahydrocannabinol-β-cyclodextrin inclusion complex

Y. Shoyama; S. Morimoto; I. Nishioka

doi:10.1021/np50029a007

Cannabis. XV. preparation and stability of Δ⁹-tetrahydrocannabinol-β-cyclodextrin inclusion complex

Y. Shoyama, S. Morimoto, I. Nishioka

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Investigation is made of the preparation of the inclusion complex of Δ9-tet-rahydrocannabinol (1) with β-cyclodextrin (β-CD) in solid form by the precipitation method. In order to estimate the inclusion complex formation, various spectral data (uv, cd, and emission spectra) have been studied. It has been estimated that the inclusion complex is highly stable under various conditions [light of 10,000 lux, oxygen existence, and high temperature (120°)} compared to 1 alone. The extensive application for a drug delivery system is also discussed.

Original language	English
Pages (from-to)	633-637
Number of pages	5
Journal	Journal of Natural Products
Volume	46
Issue number	5
DOIs	https://doi.org/10.1021/np50029a007
Publication status	Published - Sept 1983

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50029a007

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abstract = "Investigation is made of the preparation of the inclusion complex of Δ9-tet-rahydrocannabinol (1) with β-cyclodextrin (β-CD) in solid form by the precipitation method. In order to estimate the inclusion complex formation, various spectral data (uv, cd, and emission spectra) have been studied. It has been estimated that the inclusion complex is highly stable under various conditions [light of 10,000 lux, oxygen existence, and high temperature (120°)} compared to 1 alone. The extensive application for a drug delivery system is also discussed.",

author = "Y. Shoyama and S. Morimoto and I. Nishioka",

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AB - Investigation is made of the preparation of the inclusion complex of Δ9-tet-rahydrocannabinol (1) with β-cyclodextrin (β-CD) in solid form by the precipitation method. In order to estimate the inclusion complex formation, various spectral data (uv, cd, and emission spectra) have been studied. It has been estimated that the inclusion complex is highly stable under various conditions [light of 10,000 lux, oxygen existence, and high temperature (120°)} compared to 1 alone. The extensive application for a drug delivery system is also discussed.

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Cannabis. XV. preparation and stability of Δ⁹-tetrahydrocannabinol-β-cyclodextrin inclusion complex

Abstract

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