Cannabis. XV. preparation and stability of Δ9-tetrahydrocannabinol-β-cyclodextrin inclusion complex

Y. Shoyama, Satoshi Morimoto, I. Nishioka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Investigation is made of the preparation of the inclusion complex of Δ9-tet-rahydrocannabinol (1) with β-cyclodextrin (β-CD) in solid form by the precipitation method. In order to estimate the inclusion complex formation, various spectral data (uv, cd, and emission spectra) have been studied. It has been estimated that the inclusion complex is highly stable under various conditions [light of 10,000 lux, oxygen existence, and high temperature (120°)} compared to 1 alone. The extensive application for a drug delivery system is also discussed.

Original languageEnglish
Pages (from-to)633-637
Number of pages5
JournalJournal of Natural Products
Volume46
Issue number5
DOIs
Publication statusPublished - Jan 1 1983

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Dronabinol
Cyclodextrins
Cannabis
Drug Delivery Systems
Oxygen
Light
Temperature

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Cannabis. XV. preparation and stability of Δ9-tetrahydrocannabinol-β-cyclodextrin inclusion complex. / Shoyama, Y.; Morimoto, Satoshi; Nishioka, I.

In: Journal of Natural Products, Vol. 46, No. 5, 01.01.1983, p. 633-637.

Research output: Contribution to journalArticle

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