Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice

Satoshi Haramizu, Fuminori Kawabata, Koichiro Ohnuki, Naohiko Inoue, Tatsuo Watanabe, Susumu Yazawa, Tohru Fushiki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Enhancement of energy expenditure and reducing energy intake are crucial for weight control. Capsiate, a non-pungent capsaicin analog, is known to suppress body fat accumulation and reduce body weight by enhancing of energy expenditure in both mice and humans. However, it is poorly understood whether suppressing body fat accumulation by capsiate administration is equal to exercise or not. The aim of this study is to compare the effects of repeated administration of capsiate and exercise and to investigate the weight rebound after repeated capsiate administration and/or exercise. In the present study, we report that 2 weeks treatment of capsiate and exercise increased energy metabolism and suppressed body fat accumulation during 4 more weeks of ad libitum feeding. The body weight in capsiate and exercise groups was significantly lower than that of control group. The oxygen consumption was significanlty increased in capsiate and exercise groups than in the vehicle administered mice. In addition, the abdominal adipose tissue weight in capsiate and exercise groups was significantly lower than that of control group. These results indicate that suppressing body fat accumulation by capsiate intake is beneficial for maintaining an ideal body weight as exercise.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalBiomedical Research
Volume32
Issue number4
DOIs
Publication statusPublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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