Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors

Satoshi Haramizu, Wataru Mizunoya, Yoriko Masuda, Koichiro Ohnuki, Tatsuo Watanabe, Susumu Yazawa, Tohru Fushiki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We investigated the effect of capsiate, a nonpungent natural capsaicin analog, on the swimming capacity of mice in an adjustable-current water pool. Male BALB/c mice orally given capsiate (10 mg/kg) were able to keep swimming longer before exhaustion than the control mice. After 30 min of swimming, the residual glycogen in the gastrocnemius muscle was higher, the serum free fatty acid concentration tended to be higher, and the serum lactic acid concentration was significantly lower in the capsiate-administered mice. The value for the respiratory exchange ratio of the capsiate group was significantly lower during both resting and treadmill running. These physiological differences were abolished by administering the vanilloid receptor antagonist, capsazepin (0.17 mmol/kg, i.p.). The mice were not averse to the capsiate solution during a 4-h two-bottle choice test. These results suggest that the oral administration of capsiate enhanced fat oxidation and spared carbohydrate utilization, and consequently increased the endurance swimming capacity of the mice via stimulation of their vanilloid receptors. Practical application of capsiate is expected.

Original languageEnglish
Pages (from-to)774-781
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume70
Issue number4
DOIs
Publication statusPublished - May 5 2006

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TRPV Cation Channels
capsaicin
Capsaicin
Durability
receptors
mice
Exercise equipment
Bottles
Lactic acid
Carbohydrates
Oils and fats
Fatty acids
Muscle
water currents
exercise equipment
bottles
Oxidation
lactic acid
oral administration
glycogen

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. / Haramizu, Satoshi; Mizunoya, Wataru; Masuda, Yoriko; Ohnuki, Koichiro; Watanabe, Tatsuo; Yazawa, Susumu; Fushiki, Tohru.

In: Bioscience, Biotechnology and Biochemistry, Vol. 70, No. 4, 05.05.2006, p. 774-781.

Research output: Contribution to journalArticle

Haramizu, Satoshi ; Mizunoya, Wataru ; Masuda, Yoriko ; Ohnuki, Koichiro ; Watanabe, Tatsuo ; Yazawa, Susumu ; Fushiki, Tohru. / Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. In: Bioscience, Biotechnology and Biochemistry. 2006 ; Vol. 70, No. 4. pp. 774-781.
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