Abstract
Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn’s disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Results: Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Conclusions: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.
| Original language | English |
|---|---|
| Pages (from-to) | 249-260 |
| Number of pages | 12 |
| Journal | Journal of gastroenterology |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 15 2019 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
Cite this
Capsule endoscopy findings for the diagnosis of Crohn’s disease : a nationwide case–control study. / Esaki, Motohiro; Matsumoto, Takayuki; Ohmiya, Naoki; Washio, Ema; Morishita, Toshifumi; Sakamoto, Kei; Abe, Hiroo; Yamamoto, Shojiro; Kinjo, Tetsu; Togashi, Kazutomo; Watanabe, Kenji; Hirai, Fumihito; Nakamura, Masanao; Nouda, Sadaharu; Ashizuka, Shinya; Omori, Teppei; Kochi, Shuji; Yanai, Shunichi; Fuyuno, Yuta; Hirano, Atsushi; Umeno, Junji; Kitazono, Takanari; Kinjo, Fukunori; Watanabe, Mamoru; Matsui, Toshiyuki; Suzuki, Yasuo.
In: Journal of gastroenterology, Vol. 54, No. 3, 15.03.2019, p. 249-260.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Capsule endoscopy findings for the diagnosis of Crohn’s disease
T2 - a nationwide case–control study
AU - Esaki, Motohiro
AU - Matsumoto, Takayuki
AU - Ohmiya, Naoki
AU - Washio, Ema
AU - Morishita, Toshifumi
AU - Sakamoto, Kei
AU - Abe, Hiroo
AU - Yamamoto, Shojiro
AU - Kinjo, Tetsu
AU - Togashi, Kazutomo
AU - Watanabe, Kenji
AU - Hirai, Fumihito
AU - Nakamura, Masanao
AU - Nouda, Sadaharu
AU - Ashizuka, Shinya
AU - Omori, Teppei
AU - Kochi, Shuji
AU - Yanai, Shunichi
AU - Fuyuno, Yuta
AU - Hirano, Atsushi
AU - Umeno, Junji
AU - Kitazono, Takanari
AU - Kinjo, Fukunori
AU - Watanabe, Mamoru
AU - Matsui, Toshiyuki
AU - Suzuki, Yasuo
PY - 2019/3/15
Y1 - 2019/3/15
N2 - Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn’s disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Results: Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Conclusions: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.
AB - Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn’s disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Results: Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Conclusions: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.
UR - http://www.scopus.com/inward/record.url?scp=85053461236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053461236&partnerID=8YFLogxK
U2 - 10.1007/s00535-018-1507-6
DO - 10.1007/s00535-018-1507-6
M3 - Article
C2 - 30219994
AN - SCOPUS:85053461236
VL - 54
SP - 249
EP - 260
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 3
ER -