Capsule endoscopy findings for the diagnosis of Crohn’s disease: a nationwide case–control study

Motohiro Esaki, Takayuki Matsumoto, Naoki Ohmiya, Ema Washio, Toshifumi Morishita, Kei Sakamoto, Hiroo Abe, Shojiro Yamamoto, Tetsu Kinjo, Kazutomo Togashi, Kenji Watanabe, Fumihito Hirai, Masanao Nakamura, Sadaharu Nouda, Shinya Ashizuka, Teppei Omori, Shuji Kochi, Shunichi Yanai, Yuta Fuyuno, Atsushi HiranoJunji Umeno, Takanari Kitazono, Fukunori Kinjo, Mamoru Watanabe, Toshiyuki Matsui, Yasuo Suzuki

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Abstract

Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn’s disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Results: Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Conclusions: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.

Original languageEnglish
Pages (from-to)249-260
Number of pages12
JournalJournal of gastroenterology
Volume54
Issue number3
DOIs
Publication statusPublished - Mar 15 2019

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Capsule Endoscopy
Crohn Disease
Ulcer
Observer Variation
Early Diagnosis
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Esaki, M., Matsumoto, T., Ohmiya, N., Washio, E., Morishita, T., Sakamoto, K., ... Suzuki, Y. (2019). Capsule endoscopy findings for the diagnosis of Crohn’s disease: a nationwide case–control study. Journal of gastroenterology, 54(3), 249-260. https://doi.org/10.1007/s00535-018-1507-6

Capsule endoscopy findings for the diagnosis of Crohn’s disease : a nationwide case–control study. / Esaki, Motohiro; Matsumoto, Takayuki; Ohmiya, Naoki; Washio, Ema; Morishita, Toshifumi; Sakamoto, Kei; Abe, Hiroo; Yamamoto, Shojiro; Kinjo, Tetsu; Togashi, Kazutomo; Watanabe, Kenji; Hirai, Fumihito; Nakamura, Masanao; Nouda, Sadaharu; Ashizuka, Shinya; Omori, Teppei; Kochi, Shuji; Yanai, Shunichi; Fuyuno, Yuta; Hirano, Atsushi; Umeno, Junji; Kitazono, Takanari; Kinjo, Fukunori; Watanabe, Mamoru; Matsui, Toshiyuki; Suzuki, Yasuo.

In: Journal of gastroenterology, Vol. 54, No. 3, 15.03.2019, p. 249-260.

Research output: Contribution to journalArticle

Esaki, M, Matsumoto, T, Ohmiya, N, Washio, E, Morishita, T, Sakamoto, K, Abe, H, Yamamoto, S, Kinjo, T, Togashi, K, Watanabe, K, Hirai, F, Nakamura, M, Nouda, S, Ashizuka, S, Omori, T, Kochi, S, Yanai, S, Fuyuno, Y, Hirano, A, Umeno, J, Kitazono, T, Kinjo, F, Watanabe, M, Matsui, T & Suzuki, Y 2019, 'Capsule endoscopy findings for the diagnosis of Crohn’s disease: a nationwide case–control study', Journal of gastroenterology, vol. 54, no. 3, pp. 249-260. https://doi.org/10.1007/s00535-018-1507-6
Esaki, Motohiro ; Matsumoto, Takayuki ; Ohmiya, Naoki ; Washio, Ema ; Morishita, Toshifumi ; Sakamoto, Kei ; Abe, Hiroo ; Yamamoto, Shojiro ; Kinjo, Tetsu ; Togashi, Kazutomo ; Watanabe, Kenji ; Hirai, Fumihito ; Nakamura, Masanao ; Nouda, Sadaharu ; Ashizuka, Shinya ; Omori, Teppei ; Kochi, Shuji ; Yanai, Shunichi ; Fuyuno, Yuta ; Hirano, Atsushi ; Umeno, Junji ; Kitazono, Takanari ; Kinjo, Fukunori ; Watanabe, Mamoru ; Matsui, Toshiyuki ; Suzuki, Yasuo. / Capsule endoscopy findings for the diagnosis of Crohn’s disease : a nationwide case–control study. In: Journal of gastroenterology. 2019 ; Vol. 54, No. 3. pp. 249-260.
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abstract = "Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn’s disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Results: Under SBCE, cobblestone appearance (33{\%} vs. 2{\%}, p < 0.0001), longitudinal ulcers (78{\%} vs. 20{\%}, p < 0.0001), and irregular ulcers (84{\%} vs. 60{\%}, p < 0.01) were more frequently found in patients with CD. Linear erosion (90{\%} vs. 38{\%}, p < 0.0001) and irregular erosion (89{\%} vs. 64{\%}, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75{\%} vs. 9{\%}, p < 0.0001) and longitudinal (56{\%} vs. 7{\%}, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Conclusions: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.",
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T1 - Capsule endoscopy findings for the diagnosis of Crohn’s disease

T2 - a nationwide case–control study

AU - Esaki, Motohiro

AU - Matsumoto, Takayuki

AU - Ohmiya, Naoki

AU - Washio, Ema

AU - Morishita, Toshifumi

AU - Sakamoto, Kei

AU - Abe, Hiroo

AU - Yamamoto, Shojiro

AU - Kinjo, Tetsu

AU - Togashi, Kazutomo

AU - Watanabe, Kenji

AU - Hirai, Fumihito

AU - Nakamura, Masanao

AU - Nouda, Sadaharu

AU - Ashizuka, Shinya

AU - Omori, Teppei

AU - Kochi, Shuji

AU - Yanai, Shunichi

AU - Fuyuno, Yuta

AU - Hirano, Atsushi

AU - Umeno, Junji

AU - Kitazono, Takanari

AU - Kinjo, Fukunori

AU - Watanabe, Mamoru

AU - Matsui, Toshiyuki

AU - Suzuki, Yasuo

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn’s disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Results: Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Conclusions: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.

AB - Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn’s disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD. Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Types of small bowel mucosal injuries, including erosion, ulceration, and cobblestone appearance, and the alignment of diminutive lesions were compared between patients with and without CD. Inter- and intra-observer agreement in the determination of lesions was assessed in 25 pairs of SBCE from the two groups. Results: Under SBCE, cobblestone appearance (33% vs. 2%, p < 0.0001), longitudinal ulcers (78% vs. 20%, p < 0.0001), and irregular ulcers (84% vs. 60%, p < 0.01) were more frequently found in patients with CD. Linear erosion (90% vs. 38%, p < 0.0001) and irregular erosion (89% vs. 64%, p < 0.005) were also more frequent in patients with CD. Furthermore, circumferential (75% vs. 9%, p < 0.0001) and longitudinal (56% vs. 7%, p < 0.0001) alignment of diminutive lesions, mainly observed in the 1st tertile of the small bowel, was more frequent in patients with CD. Good intra-observer agreement was found for ulcers, cobblestone appearance, and lesion alignment. However, inter-observer agreement of SBCE findings differed among observers. Conclusions: Circumferential or longitudinal alignment of diminutive lesions, especially in the upper small bowel, may be a diagnostic clue for CD under SBCE, while inter-observer variations should be cautiously considered when using SBCE.

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