Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients

Yoshitaka Hirooka, Tsutomu Imaizumi, Hiroyuki Masaki, Shin Ichi Ando, Seiki Harada, Michiko Momohara, Akira Takeshita

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    177 Citations (Scopus)

    Abstract

    Animal studies suggest that some angiotensin coverting enzyme inhibitors augment endothelium-dependent vasorelaxation. We aimed to determine if captopril augments endothelium-dependent vasodilation in middle-aged hypertensive patients. By using strain-gauge plethysmography, forearm vasodilation evoked with intra-arterial acetylcholine (4, 8, 16, and 24 μg/min) or nitroprusside (0.2, 0.4, 0.8, and 1.2 μg/min) was examined before and after captopril administration (25 mg per os). Before captopril, forearm vasodilation with acetylcholine was less in hypertensive patients (n=12) than in age-matched (n=7) or young (n=7) normotensive subjects, but forearm vasodilation with nitroprusside did not differ among the three groups. Captopril improved forearm vasodilation in hypertensive patients (n=7) with acetylcholine but nitroprusside did not. In contrast, nifedipine (10 mg per os) did not alter forearm vasodilation with acetylcholine or nitroprusside in hypertensive patients (n=5). The decreases in mean blood pressure caused by captopril and nifedipine in hypertensive subjects were comparable. Captopril did not alter forearm vasodilation with acetylcholine or nitroprusside in young normotensive subjects (n=7). These results suggest that captopril in hypertensive patients may acutely improve impaired endothelium-dependent forearm vasodilation that does not result from reduction in blood pressure per se.

    Original languageEnglish
    Pages (from-to)175-180
    Number of pages6
    JournalHypertension
    Volume20
    Issue number2
    DOIs
    Publication statusPublished - Aug 1992

    All Science Journal Classification (ASJC) codes

    • Internal Medicine

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