Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients

Yoshitaka Hirooka, Tsutomu Imaizumi, Hiroyuki Masaki, Shin Ichi Ando, Seiki Harada, Michiko Momohara, Akira Takeshita

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Animal studies suggest that some angiotensin coverting enzyme inhibitors augment endothelium-dependent vasorelaxation. We aimed to determine if captopril augments endothelium-dependent vasodilation in middle-aged hypertensive patients. By using strain-gauge plethysmography, forearm vasodilation evoked with intra-arterial acetylcholine (4, 8, 16, and 24 μg/min) or nitroprusside (0.2, 0.4, 0.8, and 1.2 μg/min) was examined before and after captopril administration (25 mg per os). Before captopril, forearm vasodilation with acetylcholine was less in hypertensive patients (n=12) than in age-matched (n=7) or young (n=7) normotensive subjects, but forearm vasodilation with nitroprusside did not differ among the three groups. Captopril improved forearm vasodilation in hypertensive patients (n=7) with acetylcholine but nitroprusside did not. In contrast, nifedipine (10 mg per os) did not alter forearm vasodilation with acetylcholine or nitroprusside in hypertensive patients (n=5). The decreases in mean blood pressure caused by captopril and nifedipine in hypertensive subjects were comparable. Captopril did not alter forearm vasodilation with acetylcholine or nitroprusside in young normotensive subjects (n=7). These results suggest that captopril in hypertensive patients may acutely improve impaired endothelium-dependent forearm vasodilation that does not result from reduction in blood pressure per se.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalHypertension
Volume20
Issue number2
DOIs
Publication statusPublished - Jan 1 1992

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Captopril
Vasodilation
Endothelium
Forearm
Nitroprusside
Acetylcholine
Nifedipine
Blood Pressure
Plethysmography
Angiotensins
Enzyme Inhibitors

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Hirooka, Y., Imaizumi, T., Masaki, H., Ando, S. I., Harada, S., Momohara, M., & Takeshita, A. (1992). Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients. Hypertension, 20(2), 175-180. https://doi.org/10.1161/01.HYP.20.2.175

Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients. / Hirooka, Yoshitaka; Imaizumi, Tsutomu; Masaki, Hiroyuki; Ando, Shin Ichi; Harada, Seiki; Momohara, Michiko; Takeshita, Akira.

In: Hypertension, Vol. 20, No. 2, 01.01.1992, p. 175-180.

Research output: Contribution to journalArticle

Hirooka, Y, Imaizumi, T, Masaki, H, Ando, SI, Harada, S, Momohara, M & Takeshita, A 1992, 'Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients', Hypertension, vol. 20, no. 2, pp. 175-180. https://doi.org/10.1161/01.HYP.20.2.175
Hirooka Y, Imaizumi T, Masaki H, Ando SI, Harada S, Momohara M et al. Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients. Hypertension. 1992 Jan 1;20(2):175-180. https://doi.org/10.1161/01.HYP.20.2.175
Hirooka, Yoshitaka ; Imaizumi, Tsutomu ; Masaki, Hiroyuki ; Ando, Shin Ichi ; Harada, Seiki ; Momohara, Michiko ; Takeshita, Akira. / Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients. In: Hypertension. 1992 ; Vol. 20, No. 2. pp. 175-180.
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