Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma

Ryuma Tokunaga, Yu Imamura, Kenichi Nakamura, Tomoyuki Uchihara, Takatsugu Ishimoto, Shigeki Nakagawa, Masaaki Iwatsuki, Yoshifumi Baba, Yasuo Sakamoto, Yuji Miyamoto, Naoya Yoshida, Shinichiro Oyama, Takashi Shono, Hideaki Naoe, Hiroshi Saeki, Eiji Oki, Masayuki Watanabe, Yutaka Sasaki, Yoshihiko Maehara, Hideo Baba

Research output: Contribution to journalArticle

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Abstract

The incidence rate of esophagogastric junction (EGJ) adenocarcinoma has been rapidly increasing worldwide. Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are major serum tumor markers in gastrointestinal cancers. However, the role of these markers in EGJ adenocarcinoma has not been thoroughly investigated. A total of 211 patients with EGJ adenocarcinoma who underwent surgery or endoscopic submucosal dissection at two academic institutions, Kumamoto University Hospital or Kyushu University Hospital between January 1996 and March 2014, were eligible for this study. Serum CEA and CA19-9 were examined within 1 month before resection. The cut-off values for CEA and CA19-9 were set at 5.0 ng/mL and 37 U/mL, respectively. The clinicopathological features and prognostic roles of the markers were examined using univariate and multivariate analyses. The positive ratios for preoperative CEA (>5.0 ng/mL) and CA19-9 (>37 U/mL) were 20.3% and 12.9%, respectively. The positive ratio of CEA and CA19-9 was significantly higher in patients with tumors invading muscular or deeper layers (P = 0.002 and <0.001, respectively). Cox proportional hazards model revealed that CA19-9 positivity, but not CEA positivity, was an independent prognostic factor in patients with EGJ adenocarcinoma for cancer-specific survival (multivariate hazard ratio [HR] = 3.89, 95% confidence interval [CI] 1.41-10.33; P = 0.010) and overall survival (multivariate HR = 2.43, 95% CI 1.03-5.35; P = 0.043). Preoperative serum CA19-9 is a useful prognostic marker in patients with EGJ adenocarcinoma.

Original languageEnglish
Pages (from-to)1659-1666
Number of pages8
JournalCancer Medicine
Volume4
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

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Esophagogastric Junction
Carcinoembryonic Antigen
Adenocarcinoma
Carbohydrates
Antigens
Confidence Intervals
Gastrointestinal Neoplasms
Survival
Tumor Biomarkers
Serum
Proportional Hazards Models
Neoplasms
Multivariate Analysis
Biomarkers
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Tokunaga, R., Imamura, Y., Nakamura, K., Uchihara, T., Ishimoto, T., Nakagawa, S., ... Baba, H. (2015). Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma. Cancer Medicine, 4(11), 1659-1666. https://doi.org/10.1002/cam4.514

Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma. / Tokunaga, Ryuma; Imamura, Yu; Nakamura, Kenichi; Uchihara, Tomoyuki; Ishimoto, Takatsugu; Nakagawa, Shigeki; Iwatsuki, Masaaki; Baba, Yoshifumi; Sakamoto, Yasuo; Miyamoto, Yuji; Yoshida, Naoya; Oyama, Shinichiro; Shono, Takashi; Naoe, Hideaki; Saeki, Hiroshi; Oki, Eiji; Watanabe, Masayuki; Sasaki, Yutaka; Maehara, Yoshihiko; Baba, Hideo.

In: Cancer Medicine, Vol. 4, No. 11, 01.11.2015, p. 1659-1666.

Research output: Contribution to journalArticle

Tokunaga, R, Imamura, Y, Nakamura, K, Uchihara, T, Ishimoto, T, Nakagawa, S, Iwatsuki, M, Baba, Y, Sakamoto, Y, Miyamoto, Y, Yoshida, N, Oyama, S, Shono, T, Naoe, H, Saeki, H, Oki, E, Watanabe, M, Sasaki, Y, Maehara, Y & Baba, H 2015, 'Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma', Cancer Medicine, vol. 4, no. 11, pp. 1659-1666. https://doi.org/10.1002/cam4.514
Tokunaga R, Imamura Y, Nakamura K, Uchihara T, Ishimoto T, Nakagawa S et al. Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma. Cancer Medicine. 2015 Nov 1;4(11):1659-1666. https://doi.org/10.1002/cam4.514
Tokunaga, Ryuma ; Imamura, Yu ; Nakamura, Kenichi ; Uchihara, Tomoyuki ; Ishimoto, Takatsugu ; Nakagawa, Shigeki ; Iwatsuki, Masaaki ; Baba, Yoshifumi ; Sakamoto, Yasuo ; Miyamoto, Yuji ; Yoshida, Naoya ; Oyama, Shinichiro ; Shono, Takashi ; Naoe, Hideaki ; Saeki, Hiroshi ; Oki, Eiji ; Watanabe, Masayuki ; Sasaki, Yutaka ; Maehara, Yoshihiko ; Baba, Hideo. / Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma. In: Cancer Medicine. 2015 ; Vol. 4, No. 11. pp. 1659-1666.
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abstract = "The incidence rate of esophagogastric junction (EGJ) adenocarcinoma has been rapidly increasing worldwide. Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are major serum tumor markers in gastrointestinal cancers. However, the role of these markers in EGJ adenocarcinoma has not been thoroughly investigated. A total of 211 patients with EGJ adenocarcinoma who underwent surgery or endoscopic submucosal dissection at two academic institutions, Kumamoto University Hospital or Kyushu University Hospital between January 1996 and March 2014, were eligible for this study. Serum CEA and CA19-9 were examined within 1 month before resection. The cut-off values for CEA and CA19-9 were set at 5.0 ng/mL and 37 U/mL, respectively. The clinicopathological features and prognostic roles of the markers were examined using univariate and multivariate analyses. The positive ratios for preoperative CEA (>5.0 ng/mL) and CA19-9 (>37 U/mL) were 20.3{\%} and 12.9{\%}, respectively. The positive ratio of CEA and CA19-9 was significantly higher in patients with tumors invading muscular or deeper layers (P = 0.002 and <0.001, respectively). Cox proportional hazards model revealed that CA19-9 positivity, but not CEA positivity, was an independent prognostic factor in patients with EGJ adenocarcinoma for cancer-specific survival (multivariate hazard ratio [HR] = 3.89, 95{\%} confidence interval [CI] 1.41-10.33; P = 0.010) and overall survival (multivariate HR = 2.43, 95{\%} CI 1.03-5.35; P = 0.043). Preoperative serum CA19-9 is a useful prognostic marker in patients with EGJ adenocarcinoma.",
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