Carbohydrate side chains of Muc-1 peptide interfere with cytotoxic activity of CTL which recognize Muc-1

T. Takeda, Hidetoshi Eguchi, M. Sakon, M. Monden

Research output: Contribution to journalArticle

Abstract

Mucin is high-polymer glycoprotein that is widely distributed in various organs. Its immunogenicity is protected by long carbohydrate side chains coating the core protein. In certain types of cancer, such coating does not form normally, and the core protein is manifest, presumably showing immunogenicity. Conversely, abnormal chains may often be expressed. As a result of investigation into how much the chains are affected by cytotoxicity to the Muc-1 core proteins, it was found that the cytotoxicity of the lymphocytes recognizing the core protein portion are impeded by the carbohydrate side chains incorporating Sialyl-Tn.

Original languageEnglish
Pages (from-to)207-208
Number of pages2
JournalBiotherapy
Volume12
Issue number1
Publication statusPublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Immunology and Allergy

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