Carbon-11-methionine PET in focal cortical dysplasia: A comparison with fluorine-18-FDG PET and technetium-99m-ECD SPECT

Masayuki Sasaki, Yasuo Kuwabara, Tsuyoshi Yoshida, Toshimitsu Fukumura, Takato Morioka, Shunji Nishio, Masashi Fukui, Kouji Masuda

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Abstract

Focal cortical dysplasia is one of the known neuronal migration disorders and has recently been recognized as a cause of intractable epilepsy. In this study, we assessed the 11C-methionine (MET) uptake in focal cortical dysplasia by PET, and then compared the results with that of 18F-fluoro-2-deoxy-D-glucose (FDG) PET and 99mTc-ethyl cysteinate dimer (ECD) SPECT. Methods: Four patients (3 men, 1 woman; age range 16-68 yr) were examined by PET and SPECT for a presurgical examination of medically intractable seizures. In all 4 patients, 11C-MET PET was performed for 15 min, started 15 min after the administration of 511-662 MBq MET. In 3 of 4 patients, FDG PET was performed for 15 min, and started 20 min after the administration of 185-370 MBq FDG. In all 4 patients, the cerebral blood flow was also evaluated by 99mTc-ECD SPECT for 15 min after the administration of 600 MBq ECD. Results: In MET PET, all 4 lesions were visually recognized to have high MET uptake areas. The MET uptake of the lesions was 1.44 ± 0.30 for the standardized uptake value (SUV) (ranging from 0.99-1.61). In FDG PET, 2 lesions were demonstrated to have low uptake areas (3.82 in SUV) while 1 had an ictal high uptake (4.74 in SUV). In ECD SPECT, 1 lesion demonstrated hypoperfusion and 1 ictal hyperperfusion while 2 showed no abnormalities. All 4 patients underwent a cortical resection and the microscopic examinations were consistent with those of focal cortical dysplasia but no evidence of a tumor was found. Conclusion: MET PET is useful for identifying focal cortical dysplasia as a high uptake area.

Original languageEnglish
Pages (from-to)974-977
Number of pages4
JournalJournal of Nuclear Medicine
Volume39
Issue number6
Publication statusPublished - Jun 1 1998

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Malformations of Cortical Development
Fluorine
Technetium
Deoxyglucose
Single-Photon Emission-Computed Tomography
Methionine
Cerebrovascular Circulation
Group II Malformations of Cortical Development
Stroke
ethyl cysteinate dimer
carbon-11 methionine
Seizures

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Sasaki, M., Kuwabara, Y., Yoshida, T., Fukumura, T., Morioka, T., Nishio, S., ... Masuda, K. (1998). Carbon-11-methionine PET in focal cortical dysplasia: A comparison with fluorine-18-FDG PET and technetium-99m-ECD SPECT. Journal of Nuclear Medicine, 39(6), 974-977.

Carbon-11-methionine PET in focal cortical dysplasia : A comparison with fluorine-18-FDG PET and technetium-99m-ECD SPECT. / Sasaki, Masayuki; Kuwabara, Yasuo; Yoshida, Tsuyoshi; Fukumura, Toshimitsu; Morioka, Takato; Nishio, Shunji; Fukui, Masashi; Masuda, Kouji.

In: Journal of Nuclear Medicine, Vol. 39, No. 6, 01.06.1998, p. 974-977.

Research output: Contribution to journalArticle

Sasaki, M, Kuwabara, Y, Yoshida, T, Fukumura, T, Morioka, T, Nishio, S, Fukui, M & Masuda, K 1998, 'Carbon-11-methionine PET in focal cortical dysplasia: A comparison with fluorine-18-FDG PET and technetium-99m-ECD SPECT', Journal of Nuclear Medicine, vol. 39, no. 6, pp. 974-977.
Sasaki, Masayuki ; Kuwabara, Yasuo ; Yoshida, Tsuyoshi ; Fukumura, Toshimitsu ; Morioka, Takato ; Nishio, Shunji ; Fukui, Masashi ; Masuda, Kouji. / Carbon-11-methionine PET in focal cortical dysplasia : A comparison with fluorine-18-FDG PET and technetium-99m-ECD SPECT. In: Journal of Nuclear Medicine. 1998 ; Vol. 39, No. 6. pp. 974-977.
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N2 - Focal cortical dysplasia is one of the known neuronal migration disorders and has recently been recognized as a cause of intractable epilepsy. In this study, we assessed the 11C-methionine (MET) uptake in focal cortical dysplasia by PET, and then compared the results with that of 18F-fluoro-2-deoxy-D-glucose (FDG) PET and 99mTc-ethyl cysteinate dimer (ECD) SPECT. Methods: Four patients (3 men, 1 woman; age range 16-68 yr) were examined by PET and SPECT for a presurgical examination of medically intractable seizures. In all 4 patients, 11C-MET PET was performed for 15 min, started 15 min after the administration of 511-662 MBq MET. In 3 of 4 patients, FDG PET was performed for 15 min, and started 20 min after the administration of 185-370 MBq FDG. In all 4 patients, the cerebral blood flow was also evaluated by 99mTc-ECD SPECT for 15 min after the administration of 600 MBq ECD. Results: In MET PET, all 4 lesions were visually recognized to have high MET uptake areas. The MET uptake of the lesions was 1.44 ± 0.30 for the standardized uptake value (SUV) (ranging from 0.99-1.61). In FDG PET, 2 lesions were demonstrated to have low uptake areas (3.82 in SUV) while 1 had an ictal high uptake (4.74 in SUV). In ECD SPECT, 1 lesion demonstrated hypoperfusion and 1 ictal hyperperfusion while 2 showed no abnormalities. All 4 patients underwent a cortical resection and the microscopic examinations were consistent with those of focal cortical dysplasia but no evidence of a tumor was found. Conclusion: MET PET is useful for identifying focal cortical dysplasia as a high uptake area.

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