Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure

Sung Jae Baek, Katsutoshi Sato, Naohiro Nishida, Jun Koseki, Kazuhiko Hayashi, Koichi Kawamoto, Masamitsu Konno, Yuichiro Doki, Masaki Mori, Kazuhiko Ogawa, Hideshi Ishii

Research output: Contribution to journalArticle

Abstract

Although charged particle therapy, including carbon ion beam radiation, is a cutting-edge technology in human cancer treatment, the molecular mechanisms underlying cellular resistance to this type of therapy remain unknown. Furthermore, the chemotherapeutic agents that are most effective at overcoming cellular resistance remain unknown. In the present study, carbon ion beam radioresistant rodent cells were developed and their sensitization to trifluorothymidine (FTD), a derivative of deoxythymidine, was studied. The results of the present study demonstrated that carbon ion beam radioresistant cells were more sensitive to FTD compared with X-ray radioresistant cells. The results of the present study suggested that FTD is involved in carbon ion beam radioresistance, encouraging further study of cellular resistance to charged particle therapy for refractory human cancer.

Original languageEnglish
Pages (from-to)3389-3393
Number of pages5
JournalOncology Letters
Volume16
Issue number3
DOIs
Publication statusPublished - Sep 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Baek, S. J., Sato, K., Nishida, N., Koseki, J., Hayashi, K., Kawamoto, K., Konno, M., Doki, Y., Mori, M., Ogawa, K., & Ishii, H. (2018). Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure. Oncology Letters, 16(3), 3389-3393. https://doi.org/10.3892/ol.2018.9004