Carbonate apatite containing statin enhances bone formation in healing incisal extraction sockets in rats

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Abstract

The purpose of this study was to evaluate the feasibility of using apatite blocks fabricated by a dissolution-precipitation reaction of preset gypsum, with or without statin, to enhance bone formation during socket healing after tooth extraction. Preset gypsum blocks were immersed in a Na3PO4 aqueous solution to make hydroxyapatite (HA) low crystalline and HA containing statin (HAFS), or in a mixed solution of Na2HPO4 and NaHCO3 to make carbonate apatite (CO) and CO containing statin (COFS). The right mandibular incisors of four-week-old male Wistar rats were extracted and the sockets were filled with one of the bone substitutes or left untreated as a control (C). The animals were sacrificed at two and four weeks. Areas in the healing socket were evaluated by micro-computed tomography (micro-CT) and histological analyses. The bone volume, trabecular thickness, and trabecular separation were greatest in the COFS group, followed by the CO, HAFS, HA, and C groups. The bone mineral density of the COFS group was greater than that of the other groups when evaluated in the vertical plane. The results of this study suggest that COFS not only allowed, but also promoted, bone healing in the socket. This finding could be applicable for alveolar bone preservation after tooth extraction.

Original languageEnglish
Article number1201
JournalMaterials
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 12 2018

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Apatite
Rats
Carbonates
Bone
Durapatite
Calcium Sulfate
Hydroxyapatite
Gypsum
Bone Substitutes
Apatites
Tomography
Minerals
Dissolution
Animals
carboapatite
Crystalline materials

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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Carbonate apatite containing statin enhances bone formation in healing incisal extraction sockets in rats. / Rakhmatia, Yunia Dwi; Ayukawa, Yasunori; Furuhashi, Akihiro; Koyano, Kiyoshi.

In: Materials, Vol. 11, No. 7, 1201, 12.07.2018.

Research output: Contribution to journalArticle

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