Carboquone alters the protein synthesis of Chinese hamster V79 cell

Y. Maehara, H. Anai, H. Kusumoto, K. Sugimachi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The effect of carboquone (CQ) on protein synthesis in Chinese hamster V79 cells was determined. While the syntheses of higher molecular weight proteins decreased, the relative level of a 43-kilodalton (kd) protein increased following exposure to CQ at the concentration of 0.5 μg/ml, in a time-related fashion, determined using one-dimensional gel electrophoresis. Using two-dimensional gel electrophoresis, the 43-kd protein may be actin protein, and the syntheses of another two proteins of 8.5/45 and 48/270 (designated isoelectric point/molecular weight, kd) were increased in the CQ-treated V79 cells. These changes of the proteins induced by CQ in V79 cells were noted in HeLa cells. Three CQ-induced proteins are candidates for the elucidation of the antineoplastic effect of CQ.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
Issue number4
Publication statusPublished - 1987

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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