Carboquone alters the protein synthesis of Chinese hamster V79 cell

Y. Maehara, H. Anai, H. Kusumoto, K. Sugimachi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The effect of carboquone (CQ) on protein synthesis in Chinese hamster V79 cells was determined. While the syntheses of higher molecular weight proteins decreased, the relative level of a 43-kilodalton (kd) protein increased following exposure to CQ at the concentration of 0.5 μg/ml, in a time-related fashion, determined using one-dimensional gel electrophoresis. Using two-dimensional gel electrophoresis, the 43-kd protein may be actin protein, and the syntheses of another two proteins of 8.5/45 and 48/270 (designated isoelectric point/molecular weight, kd) were increased in the CQ-treated V79 cells. These changes of the proteins induced by CQ in V79 cells were noted in HeLa cells. Three CQ-induced proteins are candidates for the elucidation of the antineoplastic effect of CQ.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalOncology
Volume44
Issue number4
DOIs
Publication statusPublished - Jan 1 1987

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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