Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer

Rieko Izukura, Hajime Imada, Nobuko Hashiguchi, Hiroyuki Sawatari, Takayuki Ohguri, Mami Miyazono, Shin Ohta, Chiduko Takakura, Keiko Yamasaki, Chie Magota, Kanae Fujita, Hiromi Kuroda, Hideki Hirata, Tomoko Ohkusa, Akiko Chishaki

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Abstract

Purpose: Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety. Materials and methods: Thirty-one patients (age: 61 ± 12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min. Rectal temperature (T rec ), systolic and diastolic blood pressures (SBP and DBP), pulse rate (PR), respiratory rate (RR), percutaneous oxygen saturation (SpO 2 ) and sweating volume were evaluated throughout HT. Results: At 50 min after starting HT, T rec , PR and RR were significantly increased compared with the baseline values (T rec : 38.2 ± 1.4 vs. 36.3 ± 0.8 °C, p < 0.001, PR: 104 ± 15 vs. 85 ± 16 bpm, p < 0.05, RR: 23 ± 3 vs. 21 ± 3/min, p < 0.05). Although the average SBP and DBP were both stable during HT in a recumbent position, these values dropped significantly in a standing position (SBP: 113 ± 16 vs. 127 ± 18 mmHg, p < 0.001, DBP: 70 ± 12 vs. 75 ± 13 mmHg, p < 0.01). The total amount of sweating was 356 ± 173 g/m 2 on average. Conclusions: Deep regional HT increased the deep body temperature and resulted in an increase of sweating with peripheral vasodilatation. Consequently, a significant reduction in BP would be induced on standing after HT. Careful attention is needed for patients receiving HT, especially when standing after HT.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalInternational Journal of Hyperthermia
Volume33
Issue number4
DOIs
Publication statusPublished - May 19 2017

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Fever
Equipment and Supplies
Neoplasms
Sweating
Respiratory Rate
Heart Rate
Blood Pressure
Body Temperature
Posture
Vasodilation
Thorax
Oxygen
Safety
Temperature
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)
  • Cancer Research

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Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer. / Izukura, Rieko; Imada, Hajime; Hashiguchi, Nobuko; Sawatari, Hiroyuki; Ohguri, Takayuki; Miyazono, Mami; Ohta, Shin; Takakura, Chiduko; Yamasaki, Keiko; Magota, Chie; Fujita, Kanae; Kuroda, Hiromi; Hirata, Hideki; Ohkusa, Tomoko; Chishaki, Akiko.

In: International Journal of Hyperthermia, Vol. 33, No. 4, 19.05.2017, p. 428-434.

Research output: Contribution to journalArticle

Izukura, R, Imada, H, Hashiguchi, N, Sawatari, H, Ohguri, T, Miyazono, M, Ohta, S, Takakura, C, Yamasaki, K, Magota, C, Fujita, K, Kuroda, H, Hirata, H, Ohkusa, T & Chishaki, A 2017, 'Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer', International Journal of Hyperthermia, vol. 33, no. 4, pp. 428-434. https://doi.org/10.1080/02656736.2017.1283064
Izukura, Rieko ; Imada, Hajime ; Hashiguchi, Nobuko ; Sawatari, Hiroyuki ; Ohguri, Takayuki ; Miyazono, Mami ; Ohta, Shin ; Takakura, Chiduko ; Yamasaki, Keiko ; Magota, Chie ; Fujita, Kanae ; Kuroda, Hiromi ; Hirata, Hideki ; Ohkusa, Tomoko ; Chishaki, Akiko. / Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer. In: International Journal of Hyperthermia. 2017 ; Vol. 33, No. 4. pp. 428-434.
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T1 - Cardiac and respiratory effects of deep regional hyperthermia using an 8 MHz radiofrequency-capacitive device on patients with cancer

AU - Izukura, Rieko

AU - Imada, Hajime

AU - Hashiguchi, Nobuko

AU - Sawatari, Hiroyuki

AU - Ohguri, Takayuki

AU - Miyazono, Mami

AU - Ohta, Shin

AU - Takakura, Chiduko

AU - Yamasaki, Keiko

AU - Magota, Chie

AU - Fujita, Kanae

AU - Kuroda, Hiromi

AU - Hirata, Hideki

AU - Ohkusa, Tomoko

AU - Chishaki, Akiko

PY - 2017/5/19

Y1 - 2017/5/19

N2 - Purpose: Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety. Materials and methods: Thirty-one patients (age: 61 ± 12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min. Rectal temperature (T rec ), systolic and diastolic blood pressures (SBP and DBP), pulse rate (PR), respiratory rate (RR), percutaneous oxygen saturation (SpO 2 ) and sweating volume were evaluated throughout HT. Results: At 50 min after starting HT, T rec , PR and RR were significantly increased compared with the baseline values (T rec : 38.2 ± 1.4 vs. 36.3 ± 0.8 °C, p < 0.001, PR: 104 ± 15 vs. 85 ± 16 bpm, p < 0.05, RR: 23 ± 3 vs. 21 ± 3/min, p < 0.05). Although the average SBP and DBP were both stable during HT in a recumbent position, these values dropped significantly in a standing position (SBP: 113 ± 16 vs. 127 ± 18 mmHg, p < 0.001, DBP: 70 ± 12 vs. 75 ± 13 mmHg, p < 0.01). The total amount of sweating was 356 ± 173 g/m 2 on average. Conclusions: Deep regional HT increased the deep body temperature and resulted in an increase of sweating with peripheral vasodilatation. Consequently, a significant reduction in BP would be induced on standing after HT. Careful attention is needed for patients receiving HT, especially when standing after HT.

AB - Purpose: Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety. Materials and methods: Thirty-one patients (age: 61 ± 12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min. Rectal temperature (T rec ), systolic and diastolic blood pressures (SBP and DBP), pulse rate (PR), respiratory rate (RR), percutaneous oxygen saturation (SpO 2 ) and sweating volume were evaluated throughout HT. Results: At 50 min after starting HT, T rec , PR and RR were significantly increased compared with the baseline values (T rec : 38.2 ± 1.4 vs. 36.3 ± 0.8 °C, p < 0.001, PR: 104 ± 15 vs. 85 ± 16 bpm, p < 0.05, RR: 23 ± 3 vs. 21 ± 3/min, p < 0.05). Although the average SBP and DBP were both stable during HT in a recumbent position, these values dropped significantly in a standing position (SBP: 113 ± 16 vs. 127 ± 18 mmHg, p < 0.001, DBP: 70 ± 12 vs. 75 ± 13 mmHg, p < 0.01). The total amount of sweating was 356 ± 173 g/m 2 on average. Conclusions: Deep regional HT increased the deep body temperature and resulted in an increase of sweating with peripheral vasodilatation. Consequently, a significant reduction in BP would be induced on standing after HT. Careful attention is needed for patients receiving HT, especially when standing after HT.

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