Cardiac angiotensin II receptors are downregulated by chronic angiotensin II infusion in rats

M. Katoh, K. Egashira, A. Takeshita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We studied the effect of chronic (7 days) angiotensin II infusion in a subpressor (200 ng/kg per minute) dose on angiotensin II receptors in the left ventricle in rats. Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration. The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20 - 30% in the angiotensin II-infused left ventricular membranes without affecting the affinity. Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalJapanese Journal of Pharmacology
Volume84
Issue number1
DOIs
Publication statusPublished - Oct 28 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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