Cardiac angiotensin II receptors are downregulated by chronic angiotensin II infusion in rats

M. Katoh, K. Egashira, A. Takeshita

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    We studied the effect of chronic (7 days) angiotensin II infusion in a subpressor (200 ng/kg per minute) dose on angiotensin II receptors in the left ventricle in rats. Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration. The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20 - 30% in the angiotensin II-infused left ventricular membranes without affecting the affinity. Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

    Original languageEnglish
    Pages (from-to)75-77
    Number of pages3
    JournalJapanese Journal of Pharmacology
    Volume84
    Issue number1
    DOIs
    Publication statusPublished - 2000

    All Science Journal Classification (ASJC) codes

    • Pharmacology

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