Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction

Toyoharu Oba, Hideo Yasukawa, Masahiko Hoshijima, Ken Ichiro Sasaki, Nobuyoshi Futamata, Daisuke Fukui, Kazutoshi Mawatari, Takanobu Nagata, Sachiko Kyogoku, Hideki Ohshima, Tomoko Minami, Keiichiro Nakamura, Dongchon Kang, Toshitaka Yajima, Kirk U. Knowlton, Tsutomu Imaizumi

Research output: Contribution to journalArticle

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Abstract

Objectives: The study investigated the role of myocardial suppressor of cytokine signaling-3 (SOCS3), an intrinsic negative feedback regulator of the janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling pathway, in the development of left ventricular (LV) remodeling after acute myocardial infarction (AMI). Background: LV remodeling after AMI results in poor cardiac performance leading to heart failure. Although it has been shown that JAK-STATactivating cytokines prevent LV remodeling after AMI in animals, little is known about the role of SOCS3 in this process. Methods: Cardiac-specific SOCS3 knockout mice (SOCS3-CKO) were generated and subjected to AMI induced by permanent ligation of the left anterior descending coronary artery. Results: Although the initial infarct size after coronary occlusion measured by triphenyltetrazolium chloride staining was comparable between SOCS3-CKO and control mice, the infarct size 14 days after AMI was remarkably inhibited in SOCS3-CKO, indicating that progression of LV remodeling after AMI was prevented in SOCS3-CKO hearts. Prompt and marked up-regulations of multiple JAK-STATactivating cytokines including leukemia inhibitory factor and granulocyte colony-stimulating factor (G-CSF) were observed within the heart following AMI. Cardiac-specific SOCS3 deletion enhanced multiple cardioprotective signaling pathways including STAT3, AKT, and extracellular signal-regulated kinase (ERK)-1/2, while inhibiting myocardial apoptosis and fibrosis as well as augmenting antioxidant expression. Conclusions: Enhanced activation of cardioprotective signaling pathways by inhibiting myocardial SOCS3 expression prevented LV remodeling after AMI. Our data suggest that myocardial SOCS3 may be a key molecule in the development of LV remodeling after AMI.

Original languageEnglish
Pages (from-to)838-852
Number of pages15
JournalJournal of the American College of Cardiology
Volume59
Issue number9
DOIs
Publication statusPublished - Feb 28 2012

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Ventricular Remodeling
Myocardial Infarction
Cytokines
Janus Kinases
Leukemia Inhibitory Factor
Mitogen-Activated Protein Kinase 3
Coronary Occlusion
Mitogen-Activated Protein Kinase 1
Granulocyte Colony-Stimulating Factor
Transducers
Knockout Mice
Ligation
Coronary Vessels
Fibrosis
Up-Regulation
Heart Failure
Antioxidants

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. / Oba, Toyoharu; Yasukawa, Hideo; Hoshijima, Masahiko; Sasaki, Ken Ichiro; Futamata, Nobuyoshi; Fukui, Daisuke; Mawatari, Kazutoshi; Nagata, Takanobu; Kyogoku, Sachiko; Ohshima, Hideki; Minami, Tomoko; Nakamura, Keiichiro; Kang, Dongchon; Yajima, Toshitaka; Knowlton, Kirk U.; Imaizumi, Tsutomu.

In: Journal of the American College of Cardiology, Vol. 59, No. 9, 28.02.2012, p. 838-852.

Research output: Contribution to journalArticle

Oba, T, Yasukawa, H, Hoshijima, M, Sasaki, KI, Futamata, N, Fukui, D, Mawatari, K, Nagata, T, Kyogoku, S, Ohshima, H, Minami, T, Nakamura, K, Kang, D, Yajima, T, Knowlton, KU & Imaizumi, T 2012, 'Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction', Journal of the American College of Cardiology, vol. 59, no. 9, pp. 838-852. https://doi.org/10.1016/j.jacc.2011.10.887
Oba, Toyoharu ; Yasukawa, Hideo ; Hoshijima, Masahiko ; Sasaki, Ken Ichiro ; Futamata, Nobuyoshi ; Fukui, Daisuke ; Mawatari, Kazutoshi ; Nagata, Takanobu ; Kyogoku, Sachiko ; Ohshima, Hideki ; Minami, Tomoko ; Nakamura, Keiichiro ; Kang, Dongchon ; Yajima, Toshitaka ; Knowlton, Kirk U. ; Imaizumi, Tsutomu. / Cardiac-specific deletion of SOCS-3 prevents development of left ventricular remodeling after acute myocardial infarction. In: Journal of the American College of Cardiology. 2012 ; Vol. 59, No. 9. pp. 838-852.
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AU - Oba, Toyoharu

AU - Yasukawa, Hideo

AU - Hoshijima, Masahiko

AU - Sasaki, Ken Ichiro

AU - Futamata, Nobuyoshi

AU - Fukui, Daisuke

AU - Mawatari, Kazutoshi

AU - Nagata, Takanobu

AU - Kyogoku, Sachiko

AU - Ohshima, Hideki

AU - Minami, Tomoko

AU - Nakamura, Keiichiro

AU - Kang, Dongchon

AU - Yajima, Toshitaka

AU - Knowlton, Kirk U.

AU - Imaizumi, Tsutomu

PY - 2012/2/28

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N2 - Objectives: The study investigated the role of myocardial suppressor of cytokine signaling-3 (SOCS3), an intrinsic negative feedback regulator of the janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling pathway, in the development of left ventricular (LV) remodeling after acute myocardial infarction (AMI). Background: LV remodeling after AMI results in poor cardiac performance leading to heart failure. Although it has been shown that JAK-STATactivating cytokines prevent LV remodeling after AMI in animals, little is known about the role of SOCS3 in this process. Methods: Cardiac-specific SOCS3 knockout mice (SOCS3-CKO) were generated and subjected to AMI induced by permanent ligation of the left anterior descending coronary artery. Results: Although the initial infarct size after coronary occlusion measured by triphenyltetrazolium chloride staining was comparable between SOCS3-CKO and control mice, the infarct size 14 days after AMI was remarkably inhibited in SOCS3-CKO, indicating that progression of LV remodeling after AMI was prevented in SOCS3-CKO hearts. Prompt and marked up-regulations of multiple JAK-STATactivating cytokines including leukemia inhibitory factor and granulocyte colony-stimulating factor (G-CSF) were observed within the heart following AMI. Cardiac-specific SOCS3 deletion enhanced multiple cardioprotective signaling pathways including STAT3, AKT, and extracellular signal-regulated kinase (ERK)-1/2, while inhibiting myocardial apoptosis and fibrosis as well as augmenting antioxidant expression. Conclusions: Enhanced activation of cardioprotective signaling pathways by inhibiting myocardial SOCS3 expression prevented LV remodeling after AMI. Our data suggest that myocardial SOCS3 may be a key molecule in the development of LV remodeling after AMI.

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